TY - JOUR
T1 - Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease
T2 - An international verapamil SR-trandolapril ambulatory monitoring substudy
AU - Denardo, Scott J.
AU - Gong, Yan
AU - Cooper-Dehoff, Rhonda M.
AU - Farsang, Csaba
AU - Keltai, Matyas
AU - Szirmai, László
AU - Messerli, Franz H.
AU - Bavry, Anthony A.
AU - Handberg, Eileen M.
AU - Mancia, Giuseppe
AU - Pepine, Carl J.
PY - 2015/4/2
Y1 - 2015/4/2
N2 - Elevated nighttime blood pressure (BP) and heart rate (HR), increased BP and HR variability, and altered diurnal variations of BP and HR (nighttime dipping and morning surge) in patients with systemic hypertension are each associated with increased adverse cardiovascular events. However, there are no reports on the effect of hypertension treatment on these important hemodynamic parameters in the growing population of hypertensive patients with atherosclerotic coronary artery disease (CAD). This was a pre-specified subgroup analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable patients aged >50 years with hypertension and CAD randomized to either verapamil SR-oratenolol-based hypertension treatment strategies. The subgroup consisted of 117 patients undergoing 24-hour ambulatory monitoring at baseline and after 1 year of treatment. Hourly systolic and diastolic BP (SBP and DBP) decreased after 1 year for both verapamil SR- and atenolol-based treatment strategies compared with baseline (P
AB - Elevated nighttime blood pressure (BP) and heart rate (HR), increased BP and HR variability, and altered diurnal variations of BP and HR (nighttime dipping and morning surge) in patients with systemic hypertension are each associated with increased adverse cardiovascular events. However, there are no reports on the effect of hypertension treatment on these important hemodynamic parameters in the growing population of hypertensive patients with atherosclerotic coronary artery disease (CAD). This was a pre-specified subgroup analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable patients aged >50 years with hypertension and CAD randomized to either verapamil SR-oratenolol-based hypertension treatment strategies. The subgroup consisted of 117 patients undergoing 24-hour ambulatory monitoring at baseline and after 1 year of treatment. Hourly systolic and diastolic BP (SBP and DBP) decreased after 1 year for both verapamil SR- and atenolol-based treatment strategies compared with baseline (P
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U2 - 10.1371/journal.pone.0122726
DO - 10.1371/journal.pone.0122726
M3 - Article
AN - SCOPUS:84926616156
SN - 1932-6203
VL - 10
JO - PLoS One
JF - PLoS One
IS - 4
M1 - e0122726
ER -