Topiramato: Effetti sulle anomalie epilettiformi intercritiche e sull'attività EEG di fondo

F. Placidi; M. Tombini; A. Romigi; L. Bianchi; F. Izzi; F. Sperli; R. De Simone; D. Mattia; M. G. Marciani

Topiramato: Effetti sulle anomalie epilettiformi intercritiche e sull'attività EEG di fondo

Translated title of the contribution: Effects of Topiramate on interictal epileptiform abnormalities and background activity in focal epilepsy

F. Placidi, M. Tombini, A. Romigi, L. Bianchi, F. Izzi, F. Sperli, R. De Simone, D. Mattia, M. G. Marciani

Research output: Contribution to journal › Article › peer-review

Abstract

In our study we evaluated the effects of topiramate (TPM) on interictal epileptiform abnormalities (IEA) and background activity by means of a computerized EEG analysis, in twenty-four adult patients affected by symptomatic or cryptogenic focal epilepsy, with or without secondarily generalization, treated with TPM as adjunctive therapy or monotherapy. Quantitative and qualitative analysis of IEA showed a strong inhibitory effect of TPM on IEA, probably acting on the generating processes. Finally, TPM addition induced a significant reduction of seizures with only minimal interferences with EEG background activity.

Translated title of the contribution	Effects of Topiramate on interictal epileptiform abnormalities and background activity in focal epilepsy
Original language	Italian
Pages (from-to)	195-197
Number of pages	3
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	121-122
Publication status	Published - Jul 2003

ASJC Scopus subject areas

Clinical Neurology

Cite this

@article{39f07d6b738b47f093eb62e1bd779d74,

title = "Topiramato: Effetti sulle anomalie epilettiformi intercritiche e sull'attivit{\`a} EEG di fondo",

abstract = "In our study we evaluated the effects of topiramate (TPM) on interictal epileptiform abnormalities (IEA) and background activity by means of a computerized EEG analysis, in twenty-four adult patients affected by symptomatic or cryptogenic focal epilepsy, with or without secondarily generalization, treated with TPM as adjunctive therapy or monotherapy. Quantitative and qualitative analysis of IEA showed a strong inhibitory effect of TPM on IEA, probably acting on the generating processes. Finally, TPM addition induced a significant reduction of seizures with only minimal interferences with EEG background activity.",

keywords = "Background Activity, EEG, Focal Epilepsy, Interictal Epileptiform Abnormalities (IEA), Topiramate",

author = "F. Placidi and M. Tombini and A. Romigi and L. Bianchi and F. Izzi and F. Sperli and {De Simone}, R. and D. Mattia and Marciani, {M. G.}",

year = "2003",

month = jul,

language = "Italian",

pages = "195--197",

journal = "Bollettino - Lega Italiana contro l'Epilessia",

issn = "0394-560X",

publisher = "Lega Italiana contro l'Epilessia",

number = "121-122",

}

TY - JOUR

T1 - Topiramato

T2 - Effetti sulle anomalie epilettiformi intercritiche e sull'attività EEG di fondo

AU - Placidi, F.

AU - Tombini, M.

AU - Romigi, A.

AU - Bianchi, L.

AU - Izzi, F.

AU - Sperli, F.

AU - De Simone, R.

AU - Mattia, D.

AU - Marciani, M. G.

PY - 2003/7

Y1 - 2003/7

N2 - In our study we evaluated the effects of topiramate (TPM) on interictal epileptiform abnormalities (IEA) and background activity by means of a computerized EEG analysis, in twenty-four adult patients affected by symptomatic or cryptogenic focal epilepsy, with or without secondarily generalization, treated with TPM as adjunctive therapy or monotherapy. Quantitative and qualitative analysis of IEA showed a strong inhibitory effect of TPM on IEA, probably acting on the generating processes. Finally, TPM addition induced a significant reduction of seizures with only minimal interferences with EEG background activity.

AB - In our study we evaluated the effects of topiramate (TPM) on interictal epileptiform abnormalities (IEA) and background activity by means of a computerized EEG analysis, in twenty-four adult patients affected by symptomatic or cryptogenic focal epilepsy, with or without secondarily generalization, treated with TPM as adjunctive therapy or monotherapy. Quantitative and qualitative analysis of IEA showed a strong inhibitory effect of TPM on IEA, probably acting on the generating processes. Finally, TPM addition induced a significant reduction of seizures with only minimal interferences with EEG background activity.

KW - Background Activity

KW - EEG

KW - Focal Epilepsy

KW - Interictal Epileptiform Abnormalities (IEA)

KW - Topiramate

UR - http://www.scopus.com/inward/record.url?scp=1242272732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242272732&partnerID=8YFLogxK

M3 - Articolo

AN - SCOPUS:1242272732

SN - 0394-560X

SP - 195

EP - 197

JO - Bollettino - Lega Italiana contro l'Epilessia

JF - Bollettino - Lega Italiana contro l'Epilessia

IS - 121-122

ER -

Topiramato: Effetti sulle anomalie epilettiformi intercritiche e sull'attività EEG di fondo

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this