Effects of sterilization on implant mechanical property and biocompatibility

Y. H. An, F. I. Alvi, Q. Kang, M. Laberge, M. J. Drews, J. Zhang, M. A. Matthews, C. R. Arciola

Research output: Contribution to journalArticlepeer-review


This article concisely reviews the effects of sterilization on the mechanical properties and surface chemistries of implantable biomaterials. This article also summarizes the biological effects of the sterilization-related changes in the implant. Because there are so many different types of implant materials currently in use (including metals, polymers, and diverse biological materials), the response of tissue to these different materials varies dramatically. This review further discusses the effects of sterilization on in vivo and in vitro tissue response specifically to implantable metals and polyethylene, with the possibility of future biocompatibility testing of the implants sterilized with supercritical phase carbon dioxide sterifization.

Original languageEnglish
Pages (from-to)1126-1137
Number of pages12
JournalInternational Journal of Artificial Organs
Issue number11
Publication statusPublished - Nov 2005


  • Biocompatibility
  • Carbon dioxide
  • Implant
  • Mechanical properties
  • Polyethylene
  • Sterilization

ASJC Scopus subject areas

  • Biophysics


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