Effects of repetitive transcranial magnetic stimulation on spike-and-wave discharges

Antonella Conte, Francesca Gilio, Elisa Iacovelli, Chiara Marini Bettolo, Carlo Di Bonaventura, Vittorio Frasca, Antonio Carbone, Massimiliano Prencipe, Alfredo Berardelli, Maurizio Inghilleri

Research output: Contribution to journalArticlepeer-review


Aim of this study was to evaluate the effect of 5 Hz-suprathreshold repetitive transcranial magnetic stimulation (rTMS) on the duration of the spike-and-wave discharges (SWDs) in a patient presenting idiopathic absence seizures. At the moment of the study the patient presented a mild blunting of consciousness due to the high frequency of absences and EEG recordings showed sub-continuous, generalized, symmetrical and synchronous 3c/s SWDs, petit mal status. Trains of 10 stimuli (120% resting motor threshold) were delivered at 5 Hz frequency at the beginning of the SWDs. 5 Hz-rTMS trains significantly changed the EEG activity by reducing the duration of SWDs without changing the intervals between two consecutive discharges. rTMS had not significant after-effects on the epileptic activity and patient's clinical status. Despite the limitations of a single case report, our neurophysiological findings suggest that 5 Hz-suprathreshold rTMS delivered in short trains induces a transitory interference of the ongoing epileptic activity.

Original languageEnglish
Pages (from-to)140-142
Number of pages3
JournalNeuroscience Research
Issue number1
Publication statusPublished - Jan 2007


  • Absence seizures
  • Repetitive transcranial magnetic stimulation
  • Spike-and-wave discharges

ASJC Scopus subject areas

  • Neuroscience(all)


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