TY - JOUR
T1 - Effects of repetitive transcranial magnetic stimulation on spike-and-wave discharges
AU - Conte, Antonella
AU - Gilio, Francesca
AU - Iacovelli, Elisa
AU - Bettolo, Chiara Marini
AU - Di Bonaventura, Carlo
AU - Frasca, Vittorio
AU - Carbone, Antonio
AU - Prencipe, Massimiliano
AU - Berardelli, Alfredo
AU - Inghilleri, Maurizio
PY - 2007/1
Y1 - 2007/1
N2 - Aim of this study was to evaluate the effect of 5 Hz-suprathreshold repetitive transcranial magnetic stimulation (rTMS) on the duration of the spike-and-wave discharges (SWDs) in a patient presenting idiopathic absence seizures. At the moment of the study the patient presented a mild blunting of consciousness due to the high frequency of absences and EEG recordings showed sub-continuous, generalized, symmetrical and synchronous 3c/s SWDs, petit mal status. Trains of 10 stimuli (120% resting motor threshold) were delivered at 5 Hz frequency at the beginning of the SWDs. 5 Hz-rTMS trains significantly changed the EEG activity by reducing the duration of SWDs without changing the intervals between two consecutive discharges. rTMS had not significant after-effects on the epileptic activity and patient's clinical status. Despite the limitations of a single case report, our neurophysiological findings suggest that 5 Hz-suprathreshold rTMS delivered in short trains induces a transitory interference of the ongoing epileptic activity.
AB - Aim of this study was to evaluate the effect of 5 Hz-suprathreshold repetitive transcranial magnetic stimulation (rTMS) on the duration of the spike-and-wave discharges (SWDs) in a patient presenting idiopathic absence seizures. At the moment of the study the patient presented a mild blunting of consciousness due to the high frequency of absences and EEG recordings showed sub-continuous, generalized, symmetrical and synchronous 3c/s SWDs, petit mal status. Trains of 10 stimuli (120% resting motor threshold) were delivered at 5 Hz frequency at the beginning of the SWDs. 5 Hz-rTMS trains significantly changed the EEG activity by reducing the duration of SWDs without changing the intervals between two consecutive discharges. rTMS had not significant after-effects on the epileptic activity and patient's clinical status. Despite the limitations of a single case report, our neurophysiological findings suggest that 5 Hz-suprathreshold rTMS delivered in short trains induces a transitory interference of the ongoing epileptic activity.
KW - Absence seizures
KW - Repetitive transcranial magnetic stimulation
KW - Spike-and-wave discharges
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U2 - 10.1016/j.neures.2006.09.015
DO - 10.1016/j.neures.2006.09.015
M3 - Article
C2 - 17088005
AN - SCOPUS:33846043122
SN - 0168-0102
VL - 57
SP - 140
EP - 142
JO - Neuroscience Research
JF - Neuroscience Research
IS - 1
ER -