TY - JOUR
T1 - Effects of novel oral anticoagulants on left atrial and left atrial appendage thrombi
T2 - an appraisal
AU - Marsico, Fabio
AU - Cecere, Milena
AU - Parente, Antonio
AU - Paolillo, Stefania
AU - de Martino, Fabiana
AU - Dellegrottaglie, Santo
AU - Trimarco, Bruno
AU - Perrone Filardi, Pasquale
PY - 2016/9/10
Y1 - 2016/9/10
N2 - Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and predisposes to an increased risk of thromboembolic events. Patients affected by AF exhibit an increased risk of stroke compared with those in sinus rhythm, with the most common location of thrombi in the left atrial appendage. Until 2009, warfarin and other vitamin K antagonists were the only class of oral anticoagulants available. More recently, dabigatran, rivaroxaban, apixaban, and edoxaban have been approved by regulatory authorities for prevention of stroke in patients with non-valvular AF. Few data are available about the efficacy of novel oral anticoagulants for the treatment of left atrial and left atrial appendage thrombosis. Aim of this review is to summarize available evidence regarding the effectiveness of novel oral anticoagulants on left atrial appendage thrombosis.
AB - Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and predisposes to an increased risk of thromboembolic events. Patients affected by AF exhibit an increased risk of stroke compared with those in sinus rhythm, with the most common location of thrombi in the left atrial appendage. Until 2009, warfarin and other vitamin K antagonists were the only class of oral anticoagulants available. More recently, dabigatran, rivaroxaban, apixaban, and edoxaban have been approved by regulatory authorities for prevention of stroke in patients with non-valvular AF. Few data are available about the efficacy of novel oral anticoagulants for the treatment of left atrial and left atrial appendage thrombosis. Aim of this review is to summarize available evidence regarding the effectiveness of novel oral anticoagulants on left atrial appendage thrombosis.
KW - Atrial fibrillation
KW - Left atrial appendage thrombus
KW - Novel oral anticoagulants
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84986309359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84986309359&partnerID=8YFLogxK
U2 - 10.1007/s11239-016-1421-9
DO - 10.1007/s11239-016-1421-9
M3 - Article
AN - SCOPUS:84986309359
SN - 0929-5305
SP - 1
EP - 10
JO - Journal of Thrombosis and Thrombolysis
JF - Journal of Thrombosis and Thrombolysis
ER -