Effects of motor cortex stimulation on spinal interneurones in intact man

J. C. Rothwell, B. L. Day, A. Berardelli, C. D. Marsden

Research output: Contribution to journalArticlepeer-review


The effect of a descending corticospinal volley on a spinal inhibitory pathway, has been studied in five intact human subjects. Approximately 63% inhibition of the H-reflex evoked in wrist and finger flexor muscles, was produced by motor threshold stimulation of the radial nerve. When a submotor threshold cortical shock was given 2 to 4 ms before the H-reflex, this inhibition was reduced to approximately 38%. The timing of this effect is compatible with either a monosynaptic or disynaptic corticospinal tract projection onto the spinal inhibitory interneurone.

Original languageEnglish
Pages (from-to)382-384
Number of pages3
JournalExperimental Brain Research
Issue number2
Publication statusPublished - Mar 1984


  • Cortical stimulation
  • H-reflex
  • Human
  • Ia inhibition
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)


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