TY - JOUR
T1 - Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus
AU - Fogari, Roberto
AU - Derosa, Giuseppe
AU - Zoppi, Annalisa
AU - Rinaldi, Andrea
AU - Preti, Paola
AU - Lazzari, Pierangelo
AU - Mugellini, Amedeo
PY - 2008/1
Y1 - 2008/1
N2 - The purpose of this study was to compare the combination treatments of manidipine/delapril and olmesartan/hydrochlorothiazide (HCTZ) in elderly diabetic hypertensives. After a 4-week placebo period, 158 hypertensive patients with type 2 diabetes (age range: 66 to 74 years) were randomized to receive combination treatment of 10 mg manidipine plus 30 mg delapril or 20 mg olmesartan plus 12.5 mg HCTZ for 48 weeks in a prospective, parallel arm trial. After 12 weeks, manidipine or HCTZ was doubled in nonresponders (systolic blood pressure [SBP] ≥130 mmHg and/ or diastolic blood pressure [DBP] ≥:80 mmHg). Patients were checked at the end of the placebo period and every 12 weeks thereafter. At each visit, lying, sitting and standing BP as well as fasting glycernia, glycosylated hemoglobin (HbA1c), electrolytes, uric acid, total cholesterol (TC), hlgh-densfty lipoprotein-cholesterol (HDL-C) and triglycerides (TG) were evaluated. Both combinations reduced sitting SBP (-27.7 and -28.3 mmHg, respectively; both p
AB - The purpose of this study was to compare the combination treatments of manidipine/delapril and olmesartan/hydrochlorothiazide (HCTZ) in elderly diabetic hypertensives. After a 4-week placebo period, 158 hypertensive patients with type 2 diabetes (age range: 66 to 74 years) were randomized to receive combination treatment of 10 mg manidipine plus 30 mg delapril or 20 mg olmesartan plus 12.5 mg HCTZ for 48 weeks in a prospective, parallel arm trial. After 12 weeks, manidipine or HCTZ was doubled in nonresponders (systolic blood pressure [SBP] ≥130 mmHg and/ or diastolic blood pressure [DBP] ≥:80 mmHg). Patients were checked at the end of the placebo period and every 12 weeks thereafter. At each visit, lying, sitting and standing BP as well as fasting glycernia, glycosylated hemoglobin (HbA1c), electrolytes, uric acid, total cholesterol (TC), hlgh-densfty lipoprotein-cholesterol (HDL-C) and triglycerides (TG) were evaluated. Both combinations reduced sitting SBP (-27.7 and -28.3 mmHg, respectively; both p
KW - Delapril
KW - Diabetic hypertensives
KW - Hydrochlorothiazide
KW - Manidipine
KW - Olmesartan
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U2 - 10.1291/hypres.31.43
DO - 10.1291/hypres.31.43
M3 - Article
C2 - 18360017
AN - SCOPUS:40149087517
SN - 0916-9636
VL - 31
SP - 43
EP - 50
JO - Hypertension Research
JF - Hypertension Research
IS - 1
ER -