Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children

Chiara Mondino, Giovanni Ciabattoni, Pierluigi Koch, Riccardo Pistelli, Andrea Trové, Peter J. Barnes, Paolo Montuschi

Research output: Contribution to journalArticlepeer-review


Lipid mediators play an important pathophysiologic role in atopic asthmatic children, but their role in the airways of atopic nonasthmatic children is unknown. We sought (1) to measure leukotriene (LT) E 4, LTB 4, 8-isoprostane, prostaglandin E 2, and thromboxane B 2 concentrations in exhaled breath condensate in atopic asthmatic and atopic nonasthmatic children; (2) to measure exhaled nitric oxide (NO) as an independent marker of airway inflammation; and (3) to study the effect of inhaled corticosteroids on exhaled eicosanoids. Twenty healthy children, 20 atopic nonasthmatic children, 30 steroid-naive atopic asthmatic children, and 25 atopic asthmatic children receiving inhaled corticosteroids were included in a cross-sectional study. An open-label study with inhaled fluticasone (100 μg twice a day for 4 weeks) was undertaken in 14 steroid-naive atopic asthmatic children. Compared with control subjects, exhaled LTE 4 (P 4 (P 4, P =. 14; LTB 4, P =. 23; and 8-isoprostane, P =. 52). Exhaled NO levels were increased in steroid-naive atopic asthmatic children (P 4 (18%, P 4, prostaglandin E 2, or 8-isoprostane levels in steroid-naive asthmatic children. Exhaled LTE 4, LTB 4, and 8-isoprostane levels are increased in atopic asthmatic children but not in atopic nonasthmatic children. In contrast to exhaled NO, these markers seem to be relatively resistant to inhaled corticosteroids.

Original languageEnglish
Pages (from-to)761-767
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Issue number4
Publication statusPublished - Oct 2004


  • airway inflammation
  • childhood asthma
  • corticosteroids
  • exhaled breath condensate
  • exhaled nitric oxide
  • Leukotrienes
  • noninvasive markers
  • prostaglandins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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