Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas

Marcello Anti, Franco Armelao, Giancarlo Marra, Antonio Percesepe, Gianna Maria Bartoli, Paola Palozza, Paola Parrella, Ciro Canetta, Nicola Gentiloni, Italo De Vitis, Giovanni Gasbarrini

Research output: Contribution to journalArticlepeer-review


Background/Aims: Fish oil supplementation can reduce cytokinetic anomalies in the flat rectal mucosa of patients with sporadic colorectal adenoma. This study attempted to identify an optimum dose for fish oil supplementation and evaluate the persistence of its effects during long-term administration. Methods: In a double-blind study, 60 patients with sporadic adenomas received 2.5, 5.1, or 7.7 g of fish oil per day or placebo for 30 days. [3H]thymidine autoradiographic labeling indices were calculated in flat rectal mucosal biopsy specimens collected before and after supplementation. In a subsequent study, 15 patients with polyps received 2.5 g of fish oil per day. Proliferative parameters, mucosal fatty acids, and mucosal and plasma α-tocopherol levels were evaluated before, during, and after 6 months of supplementation. Results: Mean proliferative indices and mucosal arachidonic acid levels decreased significantly (and to similar degrees) in all treated groups, whereas mucosal eicosapentaenoic and docosahexaenoic acid levels increased. Significantly reduced proliferation was observed only in patients with abnormal baseline patterns. These effects persisted during long-term, lowdose treatment. A transient reduction in mucosal (but not plasma) α-tocopherol levels was observed after 1 month of treatment. Side effects were insignificant. Conclusions: Low-dose fish oil supplementation has short-term and long-term normalizing effects on the abnormal rectal proliferation patterns associated with increased colon cancer risk.

Original languageEnglish
Pages (from-to)1709-1718
Number of pages10
Issue number6
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Gastroenterology


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