Effects of a standardized oral fat load on vascular remodelling markers in healthy subjects

Giuseppe Derosa, Ilaria Ferrari, Angela D'Angelo, Sibilla A T Salvadeo, Elena Fogari, Alessia Gravina, Roberto Mereu, Ilaria Palumbo, Pamela Maffioli, Sabrina Randazzo, Arrigo F G Cicero

Research output: Contribution to journalArticlepeer-review


The most adequate way to experimentally reproduce the post-prandial lipemia condition appears to be the administration of a standardized oral fat load (OFL) to fasting patients. We studied the effects of a standardized OFL on markers of vascular remodelling in healthy subjects.We enrolled 286 Caucasians aged ≥ 18 of either sex. The OFL was given after a 12-h fast. Blood samples were drawn before and 3, 6, 9 and 12. h after the fat load. The following parameters were evaluated: body mass index (BMI), blood glucose (BG), systolic blood pressure (SBP), diastolic blood pressure (DBP), lipid profile, nitrites and nitrates, adiponectin (ADP), metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9).High density lipoprotein-cholesterol (HDL-C) decrease was present in subjects after 6. h. Triglycerides (Tg) change was observed after 6. h. Nitrites/nitrates variation was observed after 6 and 9. h during OFL. Adiponectin level was decreased after 6 and 9. h during OFL. Both MMP-2 and MMP-9 levels were higher after 6. h during OFL.We observed that nitrites/nitrates and ADP significantly decreased and MMP-2 and MMP-9 significantly increased after a standardized OFL. Other studies need to confirm the direct acute effects of post-prandial lipemia on vascular damage.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalMicrovascular Research
Issue number1
Publication statusPublished - Jul 2010


  • Cardiovascular risk
  • Endothelial dysfunction
  • Metalloproteinases
  • Post-prandial hyperlipidemia

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology


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