TY - JOUR
T1 - Effects of a standardized oral fat load on vascular remodelling markers in healthy subjects
AU - Derosa, Giuseppe
AU - Ferrari, Ilaria
AU - D'Angelo, Angela
AU - Salvadeo, Sibilla A T
AU - Fogari, Elena
AU - Gravina, Alessia
AU - Mereu, Roberto
AU - Palumbo, Ilaria
AU - Maffioli, Pamela
AU - Randazzo, Sabrina
AU - Cicero, Arrigo F G
PY - 2010/7
Y1 - 2010/7
N2 - The most adequate way to experimentally reproduce the post-prandial lipemia condition appears to be the administration of a standardized oral fat load (OFL) to fasting patients. We studied the effects of a standardized OFL on markers of vascular remodelling in healthy subjects.We enrolled 286 Caucasians aged ≥ 18 of either sex. The OFL was given after a 12-h fast. Blood samples were drawn before and 3, 6, 9 and 12. h after the fat load. The following parameters were evaluated: body mass index (BMI), blood glucose (BG), systolic blood pressure (SBP), diastolic blood pressure (DBP), lipid profile, nitrites and nitrates, adiponectin (ADP), metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9).High density lipoprotein-cholesterol (HDL-C) decrease was present in subjects after 6. h. Triglycerides (Tg) change was observed after 6. h. Nitrites/nitrates variation was observed after 6 and 9. h during OFL. Adiponectin level was decreased after 6 and 9. h during OFL. Both MMP-2 and MMP-9 levels were higher after 6. h during OFL.We observed that nitrites/nitrates and ADP significantly decreased and MMP-2 and MMP-9 significantly increased after a standardized OFL. Other studies need to confirm the direct acute effects of post-prandial lipemia on vascular damage.
AB - The most adequate way to experimentally reproduce the post-prandial lipemia condition appears to be the administration of a standardized oral fat load (OFL) to fasting patients. We studied the effects of a standardized OFL on markers of vascular remodelling in healthy subjects.We enrolled 286 Caucasians aged ≥ 18 of either sex. The OFL was given after a 12-h fast. Blood samples were drawn before and 3, 6, 9 and 12. h after the fat load. The following parameters were evaluated: body mass index (BMI), blood glucose (BG), systolic blood pressure (SBP), diastolic blood pressure (DBP), lipid profile, nitrites and nitrates, adiponectin (ADP), metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9).High density lipoprotein-cholesterol (HDL-C) decrease was present in subjects after 6. h. Triglycerides (Tg) change was observed after 6. h. Nitrites/nitrates variation was observed after 6 and 9. h during OFL. Adiponectin level was decreased after 6 and 9. h during OFL. Both MMP-2 and MMP-9 levels were higher after 6. h during OFL.We observed that nitrites/nitrates and ADP significantly decreased and MMP-2 and MMP-9 significantly increased after a standardized OFL. Other studies need to confirm the direct acute effects of post-prandial lipemia on vascular damage.
KW - Cardiovascular risk
KW - Endothelial dysfunction
KW - Metalloproteinases
KW - Post-prandial hyperlipidemia
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U2 - 10.1016/j.mvr.2010.03.012
DO - 10.1016/j.mvr.2010.03.012
M3 - Article
C2 - 20359487
AN - SCOPUS:77953536451
SN - 0026-2862
VL - 80
SP - 110
EP - 115
JO - Microvascular Research
JF - Microvascular Research
IS - 1
ER -