Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study: Diabetes, obesity & metabolism

V Cherubini; I Rabbone; MG Berioli; S Giorda; D Lo Presti; G Maltoni; C Mameli; M Marigliano; M Marino; N Minuto; E Mozzillo; E Piccinno; B Predieri; C Ripoli; R Schiaffini; A Rigamonti; G Salzano; D Tinti; S Toni; A Zanfardino; AE Scaramuzza; R Gesuita; vEC Study Group; V Tiberi; S Savastio; C Pigniatiello; M Trada; S Zucchini; FC Redaelli; C Maffeis; M Bassi; FM Rosanio; M Delvecchio; P Buzzi; MR Ricciardi; C Carducci; R Bonfanti; F Lombardo; B Piccini; D Iafusco; M Calandretti; FA Daga

doi:10.1111/dom.14491

Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study: Diabetes, obesity & metabolism

V Cherubini, I Rabbone, MG Berioli, S Giorda, D Lo Presti, G Maltoni, C Mameli, M Marigliano, M Marino, N Minuto, E Mozzillo, E Piccinno, B Predieri, C Ripoli, R Schiaffini, A Rigamonti, G Salzano, D Tinti, S Toni, A ZanfardinoAE Scaramuzza, R Gesuita, vEC Study Group, V Tiberi, S Savastio, C Pigniatiello, M Trada, S Zucchini, FC Redaelli, C Maffeis, M Bassi, FM Rosanio, M Delvecchio, P Buzzi, MR Ricciardi, C Carducci, R Bonfanti, F Lombardo, B Piccini, D Iafusco, M Calandretti, FA Daga

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and methods: This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results: Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P < .001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P < .01) and 6% (P < .01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P < .01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia. Conclusions: In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.

Original language	English
Pages (from-to)	2484-2491
Number of pages	8
Journal	Diabetes Obes. Metab.
Volume	23
Issue number	11
DOIs	https://doi.org/10.1111/dom.14491
Publication status	Published - 2021

Access to Document

10.1111/dom.14491

Cite this

Cherubini, V., Rabbone, I., Berioli, MG., Giorda, S., Lo Presti, D., Maltoni, G., Mameli, C., Marigliano, M., Marino, M., Minuto, N., Mozzillo, E., Piccinno, E., Predieri, B., Ripoli, C., Schiaffini, R., Rigamonti, A., Salzano, G., Tinti, D., Toni, S., ... Daga, FA. (2021). Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study: Diabetes, obesity & metabolism. Diabetes Obes. Metab., 23(11), 2484-2491. https://doi.org/10.1111/dom.14491

Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study : Diabetes, obesity & metabolism. / Cherubini, V; Rabbone, I; Berioli, MG et al.

In: Diabetes Obes. Metab., Vol. 23, No. 11, 2021, p. 2484-2491.

Research output: Contribution to journal › Article › peer-review

Cherubini, V, Rabbone, I, Berioli, MG, Giorda, S, Lo Presti, D, Maltoni, G, Mameli, C, Marigliano, M, Marino, M , Minuto, N, Mozzillo, E, Piccinno, E, Predieri, B, Ripoli, C , Schiaffini, R , Rigamonti, A , Salzano, G, Tinti, D, Toni, S, Zanfardino, A, Scaramuzza, AE, Gesuita, R, Group, VECS, Tiberi, V, Savastio, S, Pigniatiello, C, Trada, M, Zucchini, S, Redaelli, FC, Maffeis, C, Bassi, M, Rosanio, FM, Delvecchio, M, Buzzi, P, Ricciardi, MR, Carducci, C , Bonfanti, R, Lombardo, F, Piccini, B, Iafusco, D, Calandretti, M & Daga, FA 2021, 'Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study: Diabetes, obesity & metabolism', Diabetes Obes. Metab., vol. 23, no. 11, pp. 2484-2491. https://doi.org/10.1111/dom.14491

@article{468439645a2e460d9a09a5118ec75ed2,

title = "Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study: Diabetes, obesity & metabolism",

abstract = "Aim: To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and methods: This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results: Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P < .001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P < .01) and 6% (P < .01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P < .01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia. Conclusions: In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.",

author = "V Cherubini and I Rabbone and MG Berioli and S Giorda and {Lo Presti}, D and G Maltoni and C Mameli and M Marigliano and M Marino and N Minuto and E Mozzillo and E Piccinno and B Predieri and C Ripoli and R Schiaffini and A Rigamonti and G Salzano and D Tinti and S Toni and A Zanfardino and AE Scaramuzza and R Gesuita and Group, {vEC Study} and V Tiberi and S Savastio and C Pigniatiello and M Trada and S Zucchini and FC Redaelli and C Maffeis and M Bassi and FM Rosanio and M Delvecchio and P Buzzi and MR Ricciardi and C Carducci and R Bonfanti and F Lombardo and B Piccini and D Iafusco and M Calandretti and FA Daga",

year = "2021",

doi = "10.1111/dom.14491",

language = "English",

volume = "23",

pages = "2484--2491",

journal = "Diabetes Obes. Metab.",

issn = "1462-8902",

publisher = "Blackwell Publishing Ltd",

number = "11",

}

TY - JOUR

T1 - Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study

T2 - Diabetes, obesity & metabolism

AU - Cherubini, V

AU - Rabbone, I

AU - Berioli, MG

AU - Giorda, S

AU - Lo Presti, D

AU - Maltoni, G

AU - Mameli, C

AU - Marigliano, M

AU - Marino, M

AU - Minuto, N

AU - Mozzillo, E

AU - Piccinno, E

AU - Predieri, B

AU - Ripoli, C

AU - Schiaffini, R

AU - Rigamonti, A

AU - Salzano, G

AU - Tinti, D

AU - Toni, S

AU - Zanfardino, A

AU - Scaramuzza, AE

AU - Gesuita, R

AU - Group, vEC Study

AU - Tiberi, V

AU - Savastio, S

AU - Pigniatiello, C

AU - Trada, M

AU - Zucchini, S

AU - Redaelli, FC

AU - Maffeis, C

AU - Bassi, M

AU - Rosanio, FM

AU - Delvecchio, M

AU - Buzzi, P

AU - Ricciardi, MR

AU - Carducci, C

AU - Bonfanti, R

AU - Lombardo, F

AU - Piccini, B

AU - Iafusco, D

AU - Calandretti, M

AU - Daga, FA

PY - 2021

Y1 - 2021

N2 - Aim: To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and methods: This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results: Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P < .001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P < .01) and 6% (P < .01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P < .01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia. Conclusions: In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.

AB - Aim: To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and methods: This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results: Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P < .001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P < .01) and 6% (P < .01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P < .01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia. Conclusions: In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.

U2 - 10.1111/dom.14491

DO - 10.1111/dom.14491

M3 - Article

SN - 1462-8902

VL - 23

SP - 2484

EP - 2491

JO - Diabetes Obes. Metab.

JF - Diabetes Obes. Metab.

IS - 11

ER -

Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study: Diabetes, obesity & metabolism

Abstract

Access to Document

Fingerprint

Cite this