Effect of weight reduction on leptin, total ghrelin and obestatin concentrations in prepubertal children

T. Arrigo; E. Gitto; V. Ferraù; C. Munafò; A. Alibrandi; Gian Luigi Marseglia; A. Salpietro; M. Miraglia Del Giudice; S. Leonardi; G. Ciprandi; C. Salpietro

Effect of weight reduction on leptin, total ghrelin and obestatin concentrations in prepubertal children

T. Arrigo, E. Gitto, V. Ferraù, C. Munafò, A. Alibrandi, Gian Luigi Marseglia, A. Salpietro, M. Miraglia Del Giudice, S. Leonardi, G. Ciprandi, C. Salpietro

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of the study was to evaluate fasting levels of glucose, insulin, leptin, total ghrelin, and obestatin in a group of prepubescent obese children before and after weight loss. We enrolled 64 prepubescent obese children, but only 35 completed the study (mean age 7.6 ± 0.9 years, 19 females) and 20 normal-weight prepubescent children as controls. Fasting plasma concentration of glucose, insulin, Homeostasis Model assessment for insulin resistance (HOMA-IR), and leptin, total ghrelin, and obestatin levels were measured at baseline and after a 6-month lifestyle intervention (i.e. improved nutrition and increased physical activity). At baseline, obese children showed significantly (p

Original language	English
Journal	Journal of Biological Regulators and Homeostatic Agents
Volume	26
Issue number	1 SUPPL
Publication status	Published - 2012

Keywords

Insulin
Leptin
Obesity
Obestatin
Total ghrelin

ASJC Scopus subject areas

Oncology
Endocrinology, Diabetes and Metabolism
Physiology (medical)
Immunology and Allergy
Immunology
Endocrinology
Physiology
Cancer Research

Cite this

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abstract = "The aim of the study was to evaluate fasting levels of glucose, insulin, leptin, total ghrelin, and obestatin in a group of prepubescent obese children before and after weight loss. We enrolled 64 prepubescent obese children, but only 35 completed the study (mean age 7.6 ± 0.9 years, 19 females) and 20 normal-weight prepubescent children as controls. Fasting plasma concentration of glucose, insulin, Homeostasis Model assessment for insulin resistance (HOMA-IR), and leptin, total ghrelin, and obestatin levels were measured at baseline and after a 6-month lifestyle intervention (i.e. improved nutrition and increased physical activity). At baseline, obese children showed significantly (p",

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T1 - Effect of weight reduction on leptin, total ghrelin and obestatin concentrations in prepubertal children

AU - Arrigo, T.

AU - Gitto, E.

AU - Ferraù, V.

AU - Munafò, C.

AU - Alibrandi, A.

AU - Marseglia, Gian Luigi

AU - Salpietro, A.

AU - Miraglia Del Giudice, M.

AU - Leonardi, S.

AU - Ciprandi, G.

AU - Salpietro, C.

PY - 2012

Y1 - 2012

N2 - The aim of the study was to evaluate fasting levels of glucose, insulin, leptin, total ghrelin, and obestatin in a group of prepubescent obese children before and after weight loss. We enrolled 64 prepubescent obese children, but only 35 completed the study (mean age 7.6 ± 0.9 years, 19 females) and 20 normal-weight prepubescent children as controls. Fasting plasma concentration of glucose, insulin, Homeostasis Model assessment for insulin resistance (HOMA-IR), and leptin, total ghrelin, and obestatin levels were measured at baseline and after a 6-month lifestyle intervention (i.e. improved nutrition and increased physical activity). At baseline, obese children showed significantly (p

AB - The aim of the study was to evaluate fasting levels of glucose, insulin, leptin, total ghrelin, and obestatin in a group of prepubescent obese children before and after weight loss. We enrolled 64 prepubescent obese children, but only 35 completed the study (mean age 7.6 ± 0.9 years, 19 females) and 20 normal-weight prepubescent children as controls. Fasting plasma concentration of glucose, insulin, Homeostasis Model assessment for insulin resistance (HOMA-IR), and leptin, total ghrelin, and obestatin levels were measured at baseline and after a 6-month lifestyle intervention (i.e. improved nutrition and increased physical activity). At baseline, obese children showed significantly (p

KW - Insulin

KW - Leptin

KW - Obesity

KW - Obestatin

KW - Total ghrelin

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JO - Journal of Biological Regulators and Homeostatic Agents

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IS - 1 SUPPL

ER -

Effect of weight reduction on leptin, total ghrelin and obestatin concentrations in prepubertal children

Abstract

Keywords

ASJC Scopus subject areas

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