Effect of telmisartan addition to amlodipine on ankle edema development in treating hypertensive patients

Roberto Fogari, Annalisa Zoppi, Pamela Maffioli, Pierangelo Lazzari, Amedeo Mugellini, Giuseppe Derosa

Research output: Contribution to journalArticlepeer-review


Objective: The objective of this research was to evaluate the effect of telmisartan addition to amlodipine, on peripheral edema in hypertensive patients. Research design and methods: Seventy-five outpatients were randomized to amlodipine (A) 10 mg or telmisartan (T) 80 mg, or amlodipine 10 mg plus telmisartan 80 mg, for 6 weeks, in three crossover periods. Main outcome measures: Blood pressure, ankle foot volume (AFV) and pretibial subcutaneous tissue pressure (PSTP) were evaluated, as were plasma norepinephrine and plasma active renin (PAR). Results: Amlodipinetelmisartan combination induced greater SBP/DBP reduction (-28.1/21.7 mmHg, p <0.0001 vs baseline) compared with monotherapy with both amlodipine and telmisartan. Amlodipine monotherapy increased AFV by 26.7%, and PSTP by 83.2% (both p <0.01). Adding telmisartan to amlodipine produced a significantly lesser increase in both AFV (+7.9%, p <0.01 vs amlodipine) and PSTP (+23.8%, p <0.01 vs amlodipine). Plasma norepinephrine levels were increased by amlodipine (+134.3 pg/ml, p <0.01); such an increase was attenuated by the addition of telmisartan (+55 pg/ml, p <0.05 vs amlodipine). PAR was slightly increased by amlodipine (+21.5 pg/ml, p <0.05) and more by telmisartan alone (+62.5 pg/ml) and telmisartanamlodipine combination (+71.3 pg/ml; both p <0.01). Conclusions: The addition of telmisartan to amlodipine significantly attenuated amlodipine-induced edema formation. The reduction of amlodipine-induced reflex-sympathetic activation by telmisartan might have contributed to such an effect.

Original languageEnglish
Pages (from-to)2441-2448
Number of pages8
JournalExpert Opinion on Pharmacotherapy
Issue number16
Publication statusPublished - Nov 2011


  • amlodipine
  • ankle edema
  • hypertension
  • telmisartan

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology


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