Effect of surface properties on nanoparticle-cell interactions

Ayush Verma, Francesco Stellacci

Research output: Contribution to journalArticlepeer-review


The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.

Original languageEnglish
Pages (from-to)12-21
Number of pages10
Issue number1
Publication statusPublished - Jan 4 2010


  • Cell penetration
  • Drug delivery
  • Nanobiotechnology
  • Nanomaterials
  • Nanoparticles

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)


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