Effect of smoking on endothelium-independent vasodilatation

Gaetano A. Lanza; Francesco R. Spera; Angelo Villano; Giulio Russo; Antonino Di Franco; Priscilla Lamendola; Filippo Crea

doi:10.1016/j.atherosclerosis.2015.03.041

Effect of smoking on endothelium-independent vasodilatation

Gaetano A. Lanza, Francesco R. Spera, Angelo Villano, Giulio Russo, Antonino Di Franco, Priscilla Lamendola, Filippo Crea

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Smoking induces an impairment of endothelium-dependent vasodilatation. In this study we assessed whether smoking also causes an impairment of endothelium-independent vasodilatation. Methods: We studied 2 groups of young healthy subjects: 1) 12 medical students (24.5±0.9 years; 6 male) without cardiovascular risk factors (CVRFs), except smoking (≥10 cigarettes/day); 2) 12 matched controls (24.5±1.1 years; 6 male) without any CVRF. Nitrate-mediated dilatation (NMD) of the brachial artery was assessed in response to the random administration of 4 different doses (10, 20, 30 and 40μg) of sublingual nitroglycerin (NTG). Flow-mediated dilatation (FMD) was also assessed. Results: The increasing doses of NTG determined a progressive increase of NMD in both groups, but the dose-response curve was significantly lower in smokers compared to controls (p

Original language	English
Pages (from-to)	330-332
Number of pages	3
Journal	Atherosclerosis
Volume	240
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2015.03.041
Publication status	Published - Jun 1 2015

Keywords

Endothelial function
Nitrate-mediated dilatation
Smoking

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2015.03.041

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title = "Effect of smoking on endothelium-independent vasodilatation",

abstract = "Background: Smoking induces an impairment of endothelium-dependent vasodilatation. In this study we assessed whether smoking also causes an impairment of endothelium-independent vasodilatation. Methods: We studied 2 groups of young healthy subjects: 1) 12 medical students (24.5±0.9 years; 6 male) without cardiovascular risk factors (CVRFs), except smoking (≥10 cigarettes/day); 2) 12 matched controls (24.5±1.1 years; 6 male) without any CVRF. Nitrate-mediated dilatation (NMD) of the brachial artery was assessed in response to the random administration of 4 different doses (10, 20, 30 and 40μg) of sublingual nitroglycerin (NTG). Flow-mediated dilatation (FMD) was also assessed. Results: The increasing doses of NTG determined a progressive increase of NMD in both groups, but the dose-response curve was significantly lower in smokers compared to controls (p",

keywords = "Endothelial function, Nitrate-mediated dilatation, Smoking",

author = "Lanza, {Gaetano A.} and Spera, {Francesco R.} and Angelo Villano and Giulio Russo and {Di Franco}, Antonino and Priscilla Lamendola and Filippo Crea",

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doi = "10.1016/j.atherosclerosis.2015.03.041",

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AU - Lanza, Gaetano A.

AU - Spera, Francesco R.

AU - Villano, Angelo

AU - Russo, Giulio

AU - Di Franco, Antonino

AU - Lamendola, Priscilla

AU - Crea, Filippo

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Background: Smoking induces an impairment of endothelium-dependent vasodilatation. In this study we assessed whether smoking also causes an impairment of endothelium-independent vasodilatation. Methods: We studied 2 groups of young healthy subjects: 1) 12 medical students (24.5±0.9 years; 6 male) without cardiovascular risk factors (CVRFs), except smoking (≥10 cigarettes/day); 2) 12 matched controls (24.5±1.1 years; 6 male) without any CVRF. Nitrate-mediated dilatation (NMD) of the brachial artery was assessed in response to the random administration of 4 different doses (10, 20, 30 and 40μg) of sublingual nitroglycerin (NTG). Flow-mediated dilatation (FMD) was also assessed. Results: The increasing doses of NTG determined a progressive increase of NMD in both groups, but the dose-response curve was significantly lower in smokers compared to controls (p

AB - Background: Smoking induces an impairment of endothelium-dependent vasodilatation. In this study we assessed whether smoking also causes an impairment of endothelium-independent vasodilatation. Methods: We studied 2 groups of young healthy subjects: 1) 12 medical students (24.5±0.9 years; 6 male) without cardiovascular risk factors (CVRFs), except smoking (≥10 cigarettes/day); 2) 12 matched controls (24.5±1.1 years; 6 male) without any CVRF. Nitrate-mediated dilatation (NMD) of the brachial artery was assessed in response to the random administration of 4 different doses (10, 20, 30 and 40μg) of sublingual nitroglycerin (NTG). Flow-mediated dilatation (FMD) was also assessed. Results: The increasing doses of NTG determined a progressive increase of NMD in both groups, but the dose-response curve was significantly lower in smokers compared to controls (p

KW - Endothelial function

KW - Nitrate-mediated dilatation

KW - Smoking

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JF - Atherosclerosis

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Effect of smoking on endothelium-independent vasodilatation

Abstract

Keywords

ASJC Scopus subject areas

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