Abstract
A single oral dose of phenobarbitone 1.5 mg kg-1 was given to 18 normal subjects to evaluate the effects on lymphocyte function. Serum barbiturate concentrations and lymphocyte blastogenic response to three mitogens (PHA, Con A, PWM) were tested before and at 2, 12 and 36 h after drug administration. A serum barbiturate plateau of about 2 ng ml-1 was maintained from 2 to 36 h. Lymphocyte blastogenesis was reduced with barbiturate compared with controls. However, the reduction was significant only at 36 h (P
| Original language | English |
|---|---|
| Pages (from-to) | 1205-1207 |
| Number of pages | 3 |
| Journal | British Journal of Anaesthesia |
| Volume | 52 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1980 |
ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Mathematics(all)
- Statistics and Probability
- Agricultural and Biological Sciences (miscellaneous)
- Anesthesiology and Pain Medicine