SC-45355 (3-(12-carboxy-12-methyl)tridecyl-3-hydroxypentanedioic acid), a new analogue of 3-hydroxy-3-methylglutaric acid (HMG), has been found to inhibit the incorporation of labeled sodium acetate and labeled HMG-coenzyme A into non-saponifiable lipids, mainly cholesterol, in incubated blood mononuclear cells from normal subjects. The presence of SC-45355 in the incubation medium did not affect the incorporation of labeled mevalonate into sterols. This strongly suggests that the drug reduces cholesterol biosynthesis in incubated blood mononuclear cells by inhibiting HMG-coenzyme A reductase.
|Number of pages||9|
|Journal||Current Therapeutic Research|
|Publication status||Published - 1990|
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