Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials

S. Darby; P. McGale; C. Correa; C. Taylor; R. Arriagada; M. Clarke; D. Cutter; C. Davies; M. Ewertz; J. Godwin; R. Gray; L. Pierce; T. Whelan; Y. Wang; R. Peto; K. Albain; S. Anderson; R. Arriagada; W. Barlow; J. Bergh; J. Bliss; M. Buyse; D. Cameron; E. Carrasco; M. Clarke; C. Correa; A. Coates; R. Collins; J. Costantino; D. Cutter; J. Cuzick; S. Darby; N. Davidson; C. Davies; K. Davies; A. Delmestri; A. Di Leo; M. Dowsett; P. Elphinstone; V. Evans; M. Ewertz; R. Gelber; L. Gettins; C. Geyer; A. Goldhirsch; J. Godwin; R. Gray; C. Gregory; D. Hayes; C. Hill; J. Ingle; R. Jakesz; S. James; M. Kaufmann; A. Kerr; E. MacKinnon; P. McGale; T. McHugh; L. Norton; Y. Ohashi; S. Paik; H. C. Pan; E. Perez; R. Peto; M. Piccart; L. Pierce; K. Pritchard; G. Pruneri; V. Raina; P. Ravdin; J. Robertson; E. Rutgers; Y. F Shao; S. Swain; C. Taylor; P. Valagussa; G. Viale; T. Whelan; E. Winer; Y. Wang; W. Wood

doi:10.1016/S0140-6736(11)61629-2

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials

S. Darby, P. McGale, C. Correa, C. Taylor, R. Arriagada, M. Clarke, D. Cutter, C. Davies, M. Ewertz, J. Godwin, R. Gray, L. Pierce, T. Whelan, Y. Wang, R. Peto, K. Albain, S. Anderson, R. Arriagada, W. Barlow, J. BerghJ. Bliss, M. Buyse, D. Cameron, E. Carrasco, M. Clarke, C. Correa, A. Coates, R. Collins, J. Costantino, D. Cutter, J. Cuzick, S. Darby, N. Davidson, C. Davies, K. Davies, A. Delmestri, A. Di Leo, M. Dowsett, P. Elphinstone, V. Evans, M. Ewertz, R. Gelber, L. Gettins, C. Geyer, A. Goldhirsch, J. Godwin, R. Gray, C. Gregory, D. Hayes, C. Hill, J. Ingle, R. Jakesz, S. James, M. Kaufmann, A. Kerr, E. MacKinnon, P. McGale, T. McHugh, L. Norton, Y. Ohashi, S. Paik, H. C. Pan, E. Perez, R. Peto, M. Piccart, L. Pierce, K. Pritchard, G. Pruneri, V. Raina, P. Ravdin, J. Robertson, E. Rutgers, Y. F Shao, S. Swain, C. Taylor, P. Valagussa, G. Viale, T. Whelan, E. Winer, Y. Wang, W. Wood

Istituto Europeo di Oncologia

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Abstract

After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk. We undertook a meta-analysis of individual patient data for 10 801 women in 17 randomised trials of radiotherapy versus no radiotherapy after breast-conserving surgery, 8337 of whom had pathologically confirmed node-negative (pN0) or node-positive (pN+) disease. Overall, radiotherapy reduced the 10-year risk of any (ie, locoregional or distant) first recurrence from 35·0 to 19·3 (absolute reduction 15·7, 95 CI 13·7-17·7, 2p

Original language	English
Pages (from-to)	1707-1716
Number of pages	10
Journal	Lancet
Volume	378
Issue number	9804
DOIs	https://doi.org/10.1016/S0140-6736(11)61629-2
Publication status	Published - Nov 12 2011

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(11)61629-2

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Darby, S., McGale, P., Correa, C., Taylor, C., Arriagada, R., Clarke, M., Cutter, D., Davies, C., Ewertz, M., Godwin, J., Gray, R., Pierce, L., Whelan, T., Wang, Y., Peto, R., Albain, K., Anderson, S., Arriagada, R., Barlow, W., ... Wood, W. (2011). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials. Lancet, 378(9804), 1707-1716. https://doi.org/10.1016/S0140-6736(11)61629-2

Darby, S, McGale, P, Correa, C, Taylor, C, Arriagada, R, Clarke, M, Cutter, D, Davies, C, Ewertz, M, Godwin, J, Gray, R, Pierce, L, Whelan, T, Wang, Y, Peto, R, Albain, K, Anderson, S, Arriagada, R, Barlow, W, Bergh, J, Bliss, J, Buyse, M, Cameron, D, Carrasco, E, Clarke, M, Correa, C, Coates, A, Collins, R, Costantino, J, Cutter, D, Cuzick, J, Darby, S, Davidson, N, Davies, C, Davies, K, Delmestri, A, Di Leo, A, Dowsett, M, Elphinstone, P, Evans, V, Ewertz, M, Gelber, R, Gettins, L, Geyer, C, Goldhirsch, A, Godwin, J, Gray, R, Gregory, C, Hayes, D, Hill, C, Ingle, J, Jakesz, R, James, S, Kaufmann, M, Kerr, A, MacKinnon, E, McGale, P, McHugh, T, Norton, L, Ohashi, Y, Paik, S, Pan, HC, Perez, E, Peto, R, Piccart, M, Pierce, L, Pritchard, K, Pruneri, G, Raina, V, Ravdin, P, Robertson, J, Rutgers, E, F Shao, Y, Swain, S, Taylor, C, Valagussa, P, Viale, G, Whelan, T, Winer, E, Wang, Y & Wood, W 2011, 'Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials', Lancet, vol. 378, no. 9804, pp. 1707-1716. https://doi.org/10.1016/S0140-6736(11)61629-2

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title = "Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials",

abstract = "After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk. We undertook a meta-analysis of individual patient data for 10 801 women in 17 randomised trials of radiotherapy versus no radiotherapy after breast-conserving surgery, 8337 of whom had pathologically confirmed node-negative (pN0) or node-positive (pN+) disease. Overall, radiotherapy reduced the 10-year risk of any (ie, locoregional or distant) first recurrence from 35·0 to 19·3 (absolute reduction 15·7, 95 CI 13·7-17·7, 2p",

author = "S. Darby and P. McGale and C. Correa and C. Taylor and R. Arriagada and M. Clarke and D. Cutter and C. Davies and M. Ewertz and J. Godwin and R. Gray and L. Pierce and T. Whelan and Y. Wang and R. Peto and K. Albain and S. Anderson and R. Arriagada and W. Barlow and J. Bergh and J. Bliss and M. Buyse and D. Cameron and E. Carrasco and M. Clarke and C. Correa and A. Coates and R. Collins and J. Costantino and D. Cutter and J. Cuzick and S. Darby and N. Davidson and C. Davies and K. Davies and A. Delmestri and {Di Leo}, A. and M. Dowsett and P. Elphinstone and V. Evans and M. Ewertz and R. Gelber and L. Gettins and C. Geyer and A. Goldhirsch and J. Godwin and R. Gray and C. Gregory and D. Hayes and C. Hill and J. Ingle and R. Jakesz and S. James and M. Kaufmann and A. Kerr and E. MacKinnon and P. McGale and T. McHugh and L. Norton and Y. Ohashi and S. Paik and Pan, {H. C.} and E. Perez and R. Peto and M. Piccart and L. Pierce and K. Pritchard and G. Pruneri and V. Raina and P. Ravdin and J. Robertson and E. Rutgers and {F Shao}, Y. and S. Swain and C. Taylor and P. Valagussa and G. Viale and T. Whelan and E. Winer and Y. Wang and W. Wood",

year = "2011",

month = nov,

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doi = "10.1016/S0140-6736(11)61629-2",

language = "English",

volume = "378",

pages = "1707--1716",

journal = "The Lancet",

issn = "0140-6736",

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number = "9804",

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TY - JOUR

T1 - Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death

T2 - Meta-analysis of individual patient data for 10 801 women in 17 randomised trials

AU - Darby, S.

AU - McGale, P.

AU - Correa, C.

AU - Taylor, C.

AU - Arriagada, R.

AU - Clarke, M.

AU - Cutter, D.

AU - Davies, C.

AU - Ewertz, M.

AU - Godwin, J.

AU - Gray, R.

AU - Pierce, L.

AU - Whelan, T.

AU - Wang, Y.

AU - Peto, R.

AU - Albain, K.

AU - Anderson, S.

AU - Arriagada, R.

AU - Barlow, W.

AU - Bergh, J.

AU - Bliss, J.

AU - Buyse, M.

AU - Cameron, D.

AU - Carrasco, E.

AU - Clarke, M.

AU - Correa, C.

AU - Coates, A.

AU - Collins, R.

AU - Costantino, J.

AU - Cutter, D.

AU - Cuzick, J.

AU - Darby, S.

AU - Davidson, N.

AU - Davies, C.

AU - Davies, K.

AU - Delmestri, A.

AU - Di Leo, A.

AU - Dowsett, M.

AU - Elphinstone, P.

AU - Evans, V.

AU - Ewertz, M.

AU - Gelber, R.

AU - Gettins, L.

AU - Geyer, C.

AU - Goldhirsch, A.

AU - Godwin, J.

AU - Gray, R.

AU - Gregory, C.

AU - Hayes, D.

AU - Hill, C.

AU - Ingle, J.

AU - Jakesz, R.

AU - James, S.

AU - Kaufmann, M.

AU - Kerr, A.

AU - MacKinnon, E.

AU - McGale, P.

AU - McHugh, T.

AU - Norton, L.

AU - Ohashi, Y.

AU - Paik, S.

AU - Pan, H. C.

AU - Perez, E.

AU - Peto, R.

AU - Piccart, M.

AU - Pierce, L.

AU - Pritchard, K.

AU - Pruneri, G.

AU - Raina, V.

AU - Ravdin, P.

AU - Robertson, J.

AU - Rutgers, E.

AU - F Shao, Y.

AU - Swain, S.

AU - Taylor, C.

AU - Valagussa, P.

AU - Viale, G.

AU - Whelan, T.

AU - Winer, E.

AU - Wang, Y.

AU - Wood, W.

PY - 2011/11/12

Y1 - 2011/11/12

N2 - After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk. We undertook a meta-analysis of individual patient data for 10 801 women in 17 randomised trials of radiotherapy versus no radiotherapy after breast-conserving surgery, 8337 of whom had pathologically confirmed node-negative (pN0) or node-positive (pN+) disease. Overall, radiotherapy reduced the 10-year risk of any (ie, locoregional or distant) first recurrence from 35·0 to 19·3 (absolute reduction 15·7, 95 CI 13·7-17·7, 2p

AB - After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk. We undertook a meta-analysis of individual patient data for 10 801 women in 17 randomised trials of radiotherapy versus no radiotherapy after breast-conserving surgery, 8337 of whom had pathologically confirmed node-negative (pN0) or node-positive (pN+) disease. Overall, radiotherapy reduced the 10-year risk of any (ie, locoregional or distant) first recurrence from 35·0 to 19·3 (absolute reduction 15·7, 95 CI 13·7-17·7, 2p

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U2 - 10.1016/S0140-6736(11)61629-2

DO - 10.1016/S0140-6736(11)61629-2

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SN - 0140-6736

VL - 378

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JO - The Lancet

JF - The Lancet

IS - 9804

ER -

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials

Abstract

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