TY - JOUR
T1 - Effect of periprocedural amiodarone on procedure outcome in patients with longstanding persistent atrial fibrillation undergoing extended pulmonary vein antrum isolation
T2 - Results from a randomized study (SPECULATE)
AU - Mohanty, Sanghamitra
AU - Di Biase, Luigi
AU - Mohanty, Prasant
AU - Trivedi, Chintan
AU - Santangeli, Pasquale
AU - Bai, Rong
AU - Burkhardt, John David
AU - Gallinghouse, Joseph G.
AU - Horton, Rodney
AU - Sanchez, Javier E.
AU - Hranitzky, Patrick M.
AU - Zagrodzky, Jason
AU - Al-Ahmad, Amin
AU - Pelargonio, Gemma
AU - Lakkireddy, Dhanunjay
AU - Reddy, Madhu
AU - Forleo, Giovanni
AU - Rossillo, Antonio
AU - Themistoclakis, Sakis
AU - Hongo, Richard
AU - Beheiry, Salzwa
AU - Casella, Michela
AU - Dello Russo, Antonio
AU - Tondo, Claudio
AU - Natale, Andrea
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Background The impact of amiodarone on ablation outcome in longstanding persistent atrial fibrillation (LSPAF) patients is not known yet. Objective The purpose of this study was to assess the effect of amiodarone on procedural-outcomes in LSPAF patients undergoing catheter ablation. Methods We enrolled 112 LSPAF patients on amiodarone and scheduled to undergo atrial fibrillation (AF) ablation. Patients were randomized to amiodarone discontinuation 4 months before ablation (group 1, n = 56) and a control group (group 2, n = 56) in which ablation was performed without amiodarone discontinuation. All patients underwent pulmonary vein (PV) antrum and posterior wall isolation, defragmentation and extra PV triggers ablation. Patients were followed up for recurrence for 32 ± 8 months post-ablation. Repeat procedures in all recurrent patients were performed off amiodarone. Results During ablation, AF termination was more frequent in group 2 compared to group 1 [44 (79%) vs 32 (57%), P =.015]. After high-dosage isoproterenol, more non-PV triggers were disclosed in group 1 compared to group 2 (42 [75%] vs 24 [43%] respectively, P
AB - Background The impact of amiodarone on ablation outcome in longstanding persistent atrial fibrillation (LSPAF) patients is not known yet. Objective The purpose of this study was to assess the effect of amiodarone on procedural-outcomes in LSPAF patients undergoing catheter ablation. Methods We enrolled 112 LSPAF patients on amiodarone and scheduled to undergo atrial fibrillation (AF) ablation. Patients were randomized to amiodarone discontinuation 4 months before ablation (group 1, n = 56) and a control group (group 2, n = 56) in which ablation was performed without amiodarone discontinuation. All patients underwent pulmonary vein (PV) antrum and posterior wall isolation, defragmentation and extra PV triggers ablation. Patients were followed up for recurrence for 32 ± 8 months post-ablation. Repeat procedures in all recurrent patients were performed off amiodarone. Results During ablation, AF termination was more frequent in group 2 compared to group 1 [44 (79%) vs 32 (57%), P =.015]. After high-dosage isoproterenol, more non-PV triggers were disclosed in group 1 compared to group 2 (42 [75%] vs 24 [43%] respectively, P
KW - Amiodarone
KW - Catheterablation
KW - Longstanding persistentatrial fibrillation
KW - Nonpulmonary veintrigger
KW - Recurrence
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U2 - 10.1016/j.hrthm.2014.11.016
DO - 10.1016/j.hrthm.2014.11.016
M3 - Article
C2 - 25460855
AN - SCOPUS:84924045576
SN - 1547-5271
VL - 12
SP - 477
EP - 483
JO - Heart Rhythm
JF - Heart Rhythm
IS - 3
ER -