In the present study, we examined the effect of metadoxine on striatal levels of dopamine, S-hydroxytryptamine (5-HT) and their metabolites in male C57 Black mice. Striatal content was assayed after systemic administration of metadoxine ranging from 1 μg kg-1 to 500 mg kg-1. Striatal dopamine increased 1 h after treatment with metadoxine (150 mg kg-1), but the most notable effect was obtained 24 h after the drug administration. At this time a plateau was reached; the two major metabolites of dopamine showed the same trend. Seven days after metadoxine administration, striatal dopamine approached the control values. Over the same time intervals, striatal 5-HT increased to a lesser extent and 5-hydroxyindoleacetic acid did not differ significantly from controls. Striatal dopamine increased significantly at a dose of 250 μg kg-1 up to a dose of 1 mg kg-1 metadoxine, no further increment was observed between 1 and 500 mg kg-1 metadoxine. Administration of each component at doses equimolar to 1 mg metadoxine showed that pyridoxine produced only a mild increase in striatal dopamine compared with controls. We suggest that the metadoxine-induced striatal dopamine increase is obtained by increasing synthesis of dopamine.
|Number of pages||3|
|Journal||Journal of Pharmacy and Pharmacology|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Pharmaceutical Science