TY - JOUR
T1 - Effect of memantine on resting state default mode network activity in Alzheimer's disease
AU - Lorenzi, Marco
AU - Beltramello, Alberto
AU - Mercuri, Nicola B.
AU - Canu, Elisa
AU - Zoccatelli, Giada
AU - Pizzini, Francesca B.
AU - Alessandrini, Franco
AU - Cotelli, Maria
AU - Rosini, Sandra
AU - Costardi, Daniela
AU - Caltagirone, Carlo
AU - Frisoni, Giovanni B.
PY - 2011
Y1 - 2011
N2 - Background: Memantine is an approved symptomatic treatment for moderate to severe Alzheimer's disease that reduces the excitotoxic effects of hyperactive glutamatergic transmission. However, the exact mechanism of the effect of memantine in Alzheimer's disease patients is poorly understood. Importantly, the default mode network (DMN), which plays a key role in attention, is hypoactive in Alzheimer's disease and is under glutamatergic control. Objective: To assess the effect of memantine on the activity of the DMN in moderate to severe Alzheimer's disease. Methods: Functional magnetic resonance imaging (MRI) data from 15 patients with moderate to severe Alzheimer's disease, seven treated with memantine (mean±SD age 77±8 years, mean±SD Mini-Mental State Examination [MMSE] score 16±5) and eight with placebo (mean±SD age 76±6 years, mean±SD MMSE score 13±1), were acquired at baseline (T0) and after 6 months of treatment (T6). Resting state components were extracted after spatial normalization in individual patients with independent component analysis. The consistency of the components was assessed using ICASSO and the DMN was recognized through spatial correlation with a pre-defined template. Voxel-based statistical analyses were performed to study the change in DMN activity from T0 to T6 in the two groups. Results: At T0, the two groups showed similar DMN activity except in the precuneus and cuneus, where the patients who started treatment with memantine had slightly greater activity (p
AB - Background: Memantine is an approved symptomatic treatment for moderate to severe Alzheimer's disease that reduces the excitotoxic effects of hyperactive glutamatergic transmission. However, the exact mechanism of the effect of memantine in Alzheimer's disease patients is poorly understood. Importantly, the default mode network (DMN), which plays a key role in attention, is hypoactive in Alzheimer's disease and is under glutamatergic control. Objective: To assess the effect of memantine on the activity of the DMN in moderate to severe Alzheimer's disease. Methods: Functional magnetic resonance imaging (MRI) data from 15 patients with moderate to severe Alzheimer's disease, seven treated with memantine (mean±SD age 77±8 years, mean±SD Mini-Mental State Examination [MMSE] score 16±5) and eight with placebo (mean±SD age 76±6 years, mean±SD MMSE score 13±1), were acquired at baseline (T0) and after 6 months of treatment (T6). Resting state components were extracted after spatial normalization in individual patients with independent component analysis. The consistency of the components was assessed using ICASSO and the DMN was recognized through spatial correlation with a pre-defined template. Voxel-based statistical analyses were performed to study the change in DMN activity from T0 to T6 in the two groups. Results: At T0, the two groups showed similar DMN activity except in the precuneus and cuneus, where the patients who started treatment with memantine had slightly greater activity (p
KW - Alzheimer's-disease, treatment
KW - Memantine, therapeutic use
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UR - http://www.scopus.com/inward/citedby.url?scp=79951869793&partnerID=8YFLogxK
U2 - 10.2165/11586440-000000000-00000
DO - 10.2165/11586440-000000000-00000
M3 - Article
C2 - 21250762
AN - SCOPUS:79951869793
SN - 1170-229X
VL - 28
SP - 205
EP - 217
JO - Drugs and Aging
JF - Drugs and Aging
IS - 3
ER -