Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals

Laura Kahmann; Peter Uciechowski; Sabine Warmuth; Marco Malavolta; Eugenio Mocchegiani; Lothar Rink

doi:10.1007/s10522-006-9058-2

Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals

Laura Kahmann, Peter Uciechowski, Sabine Warmuth, Marco Malavolta, Eugenio Mocchegiani, Lothar Rink

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Mild zinc deficiency is a common condition in healthy elderly individuals leading to impaired cell-mediated immune response. Here we report the effect of improved zinc status on TH1/TH2 balance and on the activation status of T helper cells in 19 healthy elderly subjects aged 69.8 ± 5.1 years. Our investigations revealed a mild zinc deficiency which was adjusted by oral zinc supplementation for seven weeks. Improved serum zinc levels significantly reduced levels of activated T helper cells whereas changes in TH1/ TH2 ratio (determined by CCR4 and CCR5 expression) were not observed. These findings suggest that elderly individuals may benefit from moderate zinc supplementation due to improved immune response leading to reduced incidences of autoimmune diseases and infections.

Original language	English
Pages (from-to)	429-435
Number of pages	7
Journal	Biogerontology
Volume	7
Issue number	5-6
DOIs	https://doi.org/10.1007/s10522-006-9058-2
Publication status	Published - Oct 2006

Keywords

Activated T cells
CCR4/CCR5 ratio
Elderly
Serum zinc level
TH1/TH2 balance
Zinc deficiency
Zinc supplementation

ASJC Scopus subject areas

Geriatrics and Gerontology
Gerontology
Ageing

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10.1007/s10522-006-9058-2

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abstract = "Mild zinc deficiency is a common condition in healthy elderly individuals leading to impaired cell-mediated immune response. Here we report the effect of improved zinc status on TH1/TH2 balance and on the activation status of T helper cells in 19 healthy elderly subjects aged 69.8 ± 5.1 years. Our investigations revealed a mild zinc deficiency which was adjusted by oral zinc supplementation for seven weeks. Improved serum zinc levels significantly reduced levels of activated T helper cells whereas changes in TH1/ TH2 ratio (determined by CCR4 and CCR5 expression) were not observed. These findings suggest that elderly individuals may benefit from moderate zinc supplementation due to improved immune response leading to reduced incidences of autoimmune diseases and infections.",

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AU - Kahmann, Laura

AU - Uciechowski, Peter

AU - Warmuth, Sabine

AU - Malavolta, Marco

AU - Mocchegiani, Eugenio

AU - Rink, Lothar

PY - 2006/10

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N2 - Mild zinc deficiency is a common condition in healthy elderly individuals leading to impaired cell-mediated immune response. Here we report the effect of improved zinc status on TH1/TH2 balance and on the activation status of T helper cells in 19 healthy elderly subjects aged 69.8 ± 5.1 years. Our investigations revealed a mild zinc deficiency which was adjusted by oral zinc supplementation for seven weeks. Improved serum zinc levels significantly reduced levels of activated T helper cells whereas changes in TH1/ TH2 ratio (determined by CCR4 and CCR5 expression) were not observed. These findings suggest that elderly individuals may benefit from moderate zinc supplementation due to improved immune response leading to reduced incidences of autoimmune diseases and infections.

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KW - CCR4/CCR5 ratio

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Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals

Abstract

Keywords

ASJC Scopus subject areas

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