Effect of gender after transcatheter aortic valve implantation: A meta-analysis

Federico Conrotto, Fabrizio D'Ascenzo, Patrizia Presbitero, Karin H. Humphries, John G. Webb, Stephen A. O'Connor, Marie Claude Morice, Thierry Lefèvre, Costanza Grasso, Pierluigi Sbarra, Salma Taha, Pierluigi Omedè, Walter Grosso Marra, Stefano Salizzoni, Claudio Moretti, Maurizio D'Amico, Giuseppe Biondi-Zoccai, Fiorenzo Gaita, Sebastiano Marra

Research output: Contribution to journalArticlepeer-review


Background The effect of gender on patients with aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) remains to be defined. Methods MEDLINE, Cochrane Library, and Scopus databases were searched for articles describing sex differences in baseline characteristics, procedures, and outcomes. All-cause death at follow-up of at least 1 year was the primary end point, and the independent effect of female gender was evaluated with pooled analysis using a random-effect model and with meta-regression. Results Six studies with 6,645 patients were included, half of them being women presenting with lower European System for Cardiac Operative Risk Evaluation (EuroSCORE) compared with men. At 30 days, more frequent major vascular complications and major and life-threatening bleeding occurred in women, with lower rates of moderate to severe aortic regurgitation, whereas 30-day mortality was similar. After a median follow-up of 365 days (range, 365 to 730 days) all-cause mortality was 24.0% in women and 34.0% in men. A pooled analysis of the multivariable approach found female gender was significantly related to a lower risk of death (odds ratio, 0.82; 95% CI, confidence interval, 0.73 to 0.93; I2 = 0%). A meta-regression analysis showed age, ejection fraction, previous cardiovascular accident, renal insufficiency, and access site did not influence these data. Conclusions Female patients undergoing TAVI present with a lower burden of comorbidities. The counterbalance between higher rates of vascular complications but lower of valve regurgitation may explain the reduced risk for women after TAVI, independently from baseline features and access site.

Original languageEnglish
Pages (from-to)809-816
Number of pages8
JournalAnnals of Thoracic Surgery
Issue number3
Publication statusPublished - Mar 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)


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