Effect of exercise on circulating endothelial progenitor cells in microvascular angina

Giancarla Scalone, Alberto De Caterina, Antonio Maria Leone, Alessandra Tritarelli, Roberto Mollo, Gaetano Pinnacchio, Domenico D'Amario, Gaetano Antonio Lanza, Filippo Crea

Research output: Contribution to journalArticlepeer-review


Background: Circulating endothelial progenitor cells (EPCs) might limit endothelial dysfunction in patients with microvascular angina (MVA). Endothelial colony-forming cells (ECFCs; displaying the CD34+/KDR+/CD45- phenotype) are currently regarded as true EPCs. The aim of this study was to evaluate exercise-induced ECFC mobilization and platelet reactivity in patients with MVA or with obstructive coronary artery disease (CAD). Methods and Results: Exercise stress test (EST) was performed in 20 MVA patients, 20 CAD patients and 20 controls. Platelet reactivity was assessed before and after EST as formation of monocyte-platelet aggregates (MPAs) and CD41 platelet expression, without and with adenosine diphosphate (ADP) stimulation. ECFC number was measured before and 24h after EST. At rest, MPAs and CD41 platelet expression increased more with ADP in MVA patients (+71±11.0% and +37±7.5%, respectively), than in CAD patients (+37±8.6% and +19±4.5%, respectively) and controls (+29±3.5% and +21±3.1%, respectively; P

Original languageEnglish
Pages (from-to)1777-1782
Number of pages6
JournalCirculation Journal
Issue number7
Publication statusPublished - 2013


  • Endothelial progenitor cells
  • Exercise stress test
  • Microvascular angina
  • Platelet reactivity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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