TY - JOUR
T1 - Effect of exercise on circulating endothelial progenitor cells in microvascular angina
AU - Scalone, Giancarla
AU - De Caterina, Alberto
AU - Leone, Antonio Maria
AU - Tritarelli, Alessandra
AU - Mollo, Roberto
AU - Pinnacchio, Gaetano
AU - D'Amario, Domenico
AU - Lanza, Gaetano Antonio
AU - Crea, Filippo
PY - 2013
Y1 - 2013
N2 - Background: Circulating endothelial progenitor cells (EPCs) might limit endothelial dysfunction in patients with microvascular angina (MVA). Endothelial colony-forming cells (ECFCs; displaying the CD34+/KDR+/CD45- phenotype) are currently regarded as true EPCs. The aim of this study was to evaluate exercise-induced ECFC mobilization and platelet reactivity in patients with MVA or with obstructive coronary artery disease (CAD). Methods and Results: Exercise stress test (EST) was performed in 20 MVA patients, 20 CAD patients and 20 controls. Platelet reactivity was assessed before and after EST as formation of monocyte-platelet aggregates (MPAs) and CD41 platelet expression, without and with adenosine diphosphate (ADP) stimulation. ECFC number was measured before and 24h after EST. At rest, MPAs and CD41 platelet expression increased more with ADP in MVA patients (+71±11.0% and +37±7.5%, respectively), than in CAD patients (+37±8.6% and +19±4.5%, respectively) and controls (+29±3.5% and +21±3.1%, respectively; P
AB - Background: Circulating endothelial progenitor cells (EPCs) might limit endothelial dysfunction in patients with microvascular angina (MVA). Endothelial colony-forming cells (ECFCs; displaying the CD34+/KDR+/CD45- phenotype) are currently regarded as true EPCs. The aim of this study was to evaluate exercise-induced ECFC mobilization and platelet reactivity in patients with MVA or with obstructive coronary artery disease (CAD). Methods and Results: Exercise stress test (EST) was performed in 20 MVA patients, 20 CAD patients and 20 controls. Platelet reactivity was assessed before and after EST as formation of monocyte-platelet aggregates (MPAs) and CD41 platelet expression, without and with adenosine diphosphate (ADP) stimulation. ECFC number was measured before and 24h after EST. At rest, MPAs and CD41 platelet expression increased more with ADP in MVA patients (+71±11.0% and +37±7.5%, respectively), than in CAD patients (+37±8.6% and +19±4.5%, respectively) and controls (+29±3.5% and +21±3.1%, respectively; P
KW - Endothelial progenitor cells
KW - Exercise stress test
KW - Microvascular angina
KW - Platelet reactivity
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U2 - 10.1253/circj.CJ-12-0996
DO - 10.1253/circj.CJ-12-0996
M3 - Article
C2 - 23558828
AN - SCOPUS:84879366807
SN - 1346-9843
VL - 77
SP - 1777
EP - 1782
JO - Circulation Journal
JF - Circulation Journal
IS - 7
ER -