Effect of estrogen replacement therapy on bone mineral content in girls with turner syndrome

Stefano Mora, Giovanna Weber, Maria Pia Guarneri, Giuseppina Nizzoli, Donatella Pasolini, Giuseppe Chiumello

Research output: Contribution to journalArticlepeer-review


Because a close relationship between estrogen deficiency and osteoporosis has been proven, it is possible that lifelong estrogen deficiency might be the cause of osteopenia in Turner syndrome. This study was done to characterize the effect of estrogen therapy on bone mineralization in girls with Turner syndrome. Radial bone mineral content values were found to be below the 95% normal confidence interval in 44 of 49 untreated patients, aged 10.82 ± 3.45 years. An inverse correlation was found between the patients’ ages and their D bone mineral content values. The effect of beginning estrogen treatment early or late was studied in 16 girls who started the treatment before and 11 who started after age 12. Although they were still deficient compared with controls, the first group had better mineralization than the second (P =.0005). Finally, nine patients were followed prospectively during replacement therapy; their bone mineral content Δ values changed significantly (P =.02) during the follow-up period (3.17 ± 0.33 years), but the bone mineral content did not normalize. Our data show that estrogen deficiency per se does not cause osteoporosis in young girls with Turner syndrome. In fact, estrogen therapy prevented bone loss but failed to normalize the low bone mineral content values. Early treatment is preferable because it reduces the bone density deficit present in untreated patients.

Original languageEnglish
Pages (from-to)747-751
Number of pages5
JournalObstetrics and Gynecology
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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