TY - JOUR
T1 - Effect of eradication of Helicobacter pylori in children with chronic immune thrombocytopenia
T2 - A prospective, controlled, multicenter study
AU - Russo, Giovanna
AU - Miraglia, Vito
AU - Branciforte, Francesca
AU - Matarese, Sofia Maria Rosaria
AU - Zecca, Marco
AU - Bisogno, Gianni
AU - Parodi, Emilia
AU - Amendola, Giovanni
AU - Giordano, Paola
AU - Jankovic, Momcilo
AU - Corti, Annalisa
AU - Nardi, Margherita
AU - Farruggia, Piero
AU - Battisti, Laura
AU - Baronci, Carlo
AU - Palazzi, Giovanni
AU - Tucci, Fabio
AU - Ceppi, Stefania
AU - Nobili, Bruno
AU - Ramenghi, Ugo
AU - De Mattia, Domenico
AU - Notarangelo, Lucia
PY - 2011/2
Y1 - 2011/2
N2 - Background: The eradication of Helicobacter pylori has been associated with remission of immune thrombocytopenia (ITP) in approximately half of eradicated patients. Data on children are limited to small case series.Procedure: Children from 16 centers in Italy, who were less than 18 years of age and diagnosed with chronic ITP (cITP), were screened for H. pylori infection. Positive patients underwent standard triple therapy with amoxicillin, clarithromycin, and omeprazole. The eradication response was defined as follows: complete response, platelet (PLT) count ≥150-×-109/L; partial response, PLT count of at least 50-×-109/L; no response, PLT count 9/L.Results: Of 244 screened patients, 50 (20%) had H. pylori infection, 37 of which received eradication therapy and completed follow-up. Eradication was successful in 33/37 patients (89%). PLT recovery was demonstrated in 13/33 patients after eradication (39%), whereas spontaneous remission was observed in 17/166 (10%) H. pylori-negative patients (P-
AB - Background: The eradication of Helicobacter pylori has been associated with remission of immune thrombocytopenia (ITP) in approximately half of eradicated patients. Data on children are limited to small case series.Procedure: Children from 16 centers in Italy, who were less than 18 years of age and diagnosed with chronic ITP (cITP), were screened for H. pylori infection. Positive patients underwent standard triple therapy with amoxicillin, clarithromycin, and omeprazole. The eradication response was defined as follows: complete response, platelet (PLT) count ≥150-×-109/L; partial response, PLT count of at least 50-×-109/L; no response, PLT count 9/L.Results: Of 244 screened patients, 50 (20%) had H. pylori infection, 37 of which received eradication therapy and completed follow-up. Eradication was successful in 33/37 patients (89%). PLT recovery was demonstrated in 13/33 patients after eradication (39%), whereas spontaneous remission was observed in 17/166 (10%) H. pylori-negative patients (P-
KW - Children
KW - Chronic ITP
KW - Helicobacter pylori
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U2 - 10.1002/pbc.22770
DO - 10.1002/pbc.22770
M3 - Article
C2 - 20830773
AN - SCOPUS:78650109774
SN - 1545-5009
VL - 56
SP - 273
EP - 278
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 2
ER -