Effect of electrode distance in electrochemotherapy: From numerical model to in vitro tests

A. Ongaro; L. G. Campana; M. De Mattei; F. Dughiero; M. Forzan; A. Pellati; Elisabetta Sieni; C. R. Rossi

doi:10.1007/978-981-287-817-5_37

Effect of electrode distance in electrochemotherapy: From numerical model to in vitro tests

A. Ongaro, L. G. Campana, M. De Mattei, F. Dughiero, M. Forzan, A. Pellati, Elisabetta Sieni, C. R. Rossi

Istituto Oncologico Veneto

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this paper, the electric field generated in a conductive medium by needles pairs with inter-needle distance of 1 or 2 cm has been studied by means of 3D numerical models. The computational results have been correlated with experimental ones obtained in vitro on cultured cells. In particular, electroporation effect has been assessed on human osteosarcoma cell line MG63 cultured in monolayer. These results are helpful to evaluate the effect of the needle distance on the electric field distribution in cultured cells in terms of occurrence of reversible or irreversible electroporation.

Original language	English
Title of host publication	IFMBE Proceedings
Publisher	Springer Verlag
Pages	167-170
Number of pages	4
Volume	53
ISBN (Print)	9789812878168
DOIs	https://doi.org/10.1007/978-981-287-817-5_37
Publication status	Published - 2016
Event	1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015 - Portoroz, Slovenia Duration: Sept 6 2015 → Sept 10 2015

Other

Other	1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015
Country/Territory	Slovenia
City	Portoroz
Period	9/6/15 → 9/10/15

Keywords

Electric field
Electrode
Electroporation
Propidium iodide
Reversible and irreversible electroporation

ASJC Scopus subject areas

Biomedical Engineering
Bioengineering

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10.1007/978-981-287-817-5_37

Cite this

Ongaro, A, Campana, LG, De Mattei, M, Dughiero, F, Forzan, M, Pellati, A, Sieni, E & Rossi, CR 2016, Effect of electrode distance in electrochemotherapy: From numerical model to in vitro tests. in IFMBE Proceedings. vol. 53, Springer Verlag, pp. 167-170, 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015, Portoroz, Slovenia, 9/6/15. https://doi.org/10.1007/978-981-287-817-5_37

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title = "Effect of electrode distance in electrochemotherapy: From numerical model to in vitro tests",

abstract = "In this paper, the electric field generated in a conductive medium by needles pairs with inter-needle distance of 1 or 2 cm has been studied by means of 3D numerical models. The computational results have been correlated with experimental ones obtained in vitro on cultured cells. In particular, electroporation effect has been assessed on human osteosarcoma cell line MG63 cultured in monolayer. These results are helpful to evaluate the effect of the needle distance on the electric field distribution in cultured cells in terms of occurrence of reversible or irreversible electroporation.",

keywords = "Electric field, Electrode, Electroporation, Propidium iodide, Reversible and irreversible electroporation",

author = "A. Ongaro and Campana, {L. G.} and {De Mattei}, M. and F. Dughiero and M. Forzan and A. Pellati and Elisabetta Sieni and Rossi, {C. R.}",

note = "Conference Paper - non valutabile per RC 2016, non inserito in SIPS; 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015 ; Conference date: 06-09-2015 Through 10-09-2015",

year = "2016",

doi = "10.1007/978-981-287-817-5_37",

language = "English",

isbn = "9789812878168",

volume = "53",

pages = "167--170",

booktitle = "IFMBE Proceedings",

publisher = "Springer Verlag",

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T1 - Effect of electrode distance in electrochemotherapy

T2 - 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015

AU - Ongaro, A.

AU - Campana, L. G.

AU - De Mattei, M.

AU - Dughiero, F.

AU - Forzan, M.

AU - Pellati, A.

AU - Sieni, Elisabetta

AU - Rossi, C. R.

N1 - Conference Paper - non valutabile per RC 2016, non inserito in SIPS

PY - 2016

Y1 - 2016

N2 - In this paper, the electric field generated in a conductive medium by needles pairs with inter-needle distance of 1 or 2 cm has been studied by means of 3D numerical models. The computational results have been correlated with experimental ones obtained in vitro on cultured cells. In particular, electroporation effect has been assessed on human osteosarcoma cell line MG63 cultured in monolayer. These results are helpful to evaluate the effect of the needle distance on the electric field distribution in cultured cells in terms of occurrence of reversible or irreversible electroporation.

AB - In this paper, the electric field generated in a conductive medium by needles pairs with inter-needle distance of 1 or 2 cm has been studied by means of 3D numerical models. The computational results have been correlated with experimental ones obtained in vitro on cultured cells. In particular, electroporation effect has been assessed on human osteosarcoma cell line MG63 cultured in monolayer. These results are helpful to evaluate the effect of the needle distance on the electric field distribution in cultured cells in terms of occurrence of reversible or irreversible electroporation.

KW - Electric field

KW - Electrode

KW - Electroporation

KW - Propidium iodide

KW - Reversible and irreversible electroporation

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DO - 10.1007/978-981-287-817-5_37

M3 - Conference contribution

AN - SCOPUS:84946058497

SN - 9789812878168

VL - 53

SP - 167

EP - 170

BT - IFMBE Proceedings

PB - Springer Verlag

Y2 - 6 September 2015 through 10 September 2015

ER -

Effect of electrode distance in electrochemotherapy: From numerical model to in vitro tests

Abstract

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Keywords

ASJC Scopus subject areas

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