TY - JOUR
T1 - Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer
T2 - A randomized study
AU - Campagnoli, Carlo
AU - Pasanisi, Patrizia
AU - Abbà, Chiara
AU - Ambroggio, Simona
AU - Biglia, Nicoletta
AU - Brucato, Tiziana
AU - Colombero, Raffaella
AU - Danese, Saverio
AU - Donadio, Michela
AU - Venturelli, Elisabetta
AU - Zito, Gianna
AU - Berrino, Franco
PY - 2012
Y1 - 2012
N2 - Background: Serum levels of insulin and testosterone may affect both breast cancer (BC) incidence and prognosis. Metformin reduces hyperglycemia and insulin levels in patients with diabetes. In women without diabetes and with polycystic ovary syndrome, metformin lowers both insulin and testosterone levels. Patients with diabetes who are treated with metformin showed a lower risk of cancer; a protective effect of metformin also was observed for BC. Recently, studies on metformin use for prevention or treatment of BC have been proposed in patients who are not diabetic. The aim of the present study was to test the effect of different doses of metformin on serum levels of insulin and testosterone in those postmenopausal patients with breast cancer and without diabetes who have basal testosterone levels
AB - Background: Serum levels of insulin and testosterone may affect both breast cancer (BC) incidence and prognosis. Metformin reduces hyperglycemia and insulin levels in patients with diabetes. In women without diabetes and with polycystic ovary syndrome, metformin lowers both insulin and testosterone levels. Patients with diabetes who are treated with metformin showed a lower risk of cancer; a protective effect of metformin also was observed for BC. Recently, studies on metformin use for prevention or treatment of BC have been proposed in patients who are not diabetic. The aim of the present study was to test the effect of different doses of metformin on serum levels of insulin and testosterone in those postmenopausal patients with breast cancer and without diabetes who have basal testosterone levels
KW - Breast cancer
KW - Insulin
KW - Metformin
KW - Randomized trial
KW - Testosterone
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U2 - 10.1016/j.clbc.2012.03.004
DO - 10.1016/j.clbc.2012.03.004
M3 - Article
C2 - 22607767
AN - SCOPUS:84861155928
SN - 1526-8209
VL - 12
SP - 175
EP - 182
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
IS - 3
ER -