Effect of ccl4 intoxication on the synthesis of β-lipoprotein fractions in rat liver

O. Albano; A. Francavilla

Effect of ccl4 intoxication on the synthesis of β-lipoprotein fractions in rat liver

O. Albano, A. Francavilla

Ente Ospedaliero Specializzato in Gastroenterologia "Saverio de Bellis"

Research output: Contribution to journal › Article › peer-review

Abstract

The incorporation of [¹⁴C]leucine and [³H]palmitic acid into the β-lipoproteins of liver and plasma of normal and CCl₄-intoxicated rats has been studied. It has been found that CCl₄, inhibits the incorporation of [¹⁴C]leucine and [³H]palmitic acid into β-lipoproteins isolated from the liver and the plasma and causes an increase in the ³H/¹⁴C ratio. The very low density and the low-density lipoprotein fractions were also isolated from rat liver cellular sap. Inhibition of incorporation of both substances is much more marked at the expense of the very low density fraction.

Original language	English
Pages (from-to)	363-366
Number of pages	4
Journal	Clinica Chimica Acta
Volume	19
Issue number	3
Publication status	Published - Mar 1968

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry

Cite this

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AU - Francavilla, A.

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N2 - The incorporation of [14C]leucine and [3H]palmitic acid into the β-lipoproteins of liver and plasma of normal and CCl4-intoxicated rats has been studied. It has been found that CCl4, inhibits the incorporation of [14C]leucine and [3H]palmitic acid into β-lipoproteins isolated from the liver and the plasma and causes an increase in the 3H/14C ratio. The very low density and the low-density lipoprotein fractions were also isolated from rat liver cellular sap. Inhibition of incorporation of both substances is much more marked at the expense of the very low density fraction.

AB - The incorporation of [14C]leucine and [3H]palmitic acid into the β-lipoproteins of liver and plasma of normal and CCl4-intoxicated rats has been studied. It has been found that CCl4, inhibits the incorporation of [14C]leucine and [3H]palmitic acid into β-lipoproteins isolated from the liver and the plasma and causes an increase in the 3H/14C ratio. The very low density and the low-density lipoprotein fractions were also isolated from rat liver cellular sap. Inhibition of incorporation of both substances is much more marked at the expense of the very low density fraction.

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Effect of ccl4 intoxication on the synthesis of β-lipoprotein fractions in rat liver

Abstract

ASJC Scopus subject areas

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