Effect of aspirin on the fibrinolytic response in perfused rat hindquarters

Licia Iacoviello, Amalia De Curtis, Concetta Amore, Maria Cristina D'Adamo, Wlodzimierz Buczko, Giovanni de Gaetano, Maria Benedetta Donati

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The role of aspirin in tissue plasminogen activator (t-PA) release was studied in rats after experimental venous occlusion. For this purpose, we developed a new experimental model which combines a vascular perfusion system (isolated rat hindquarters) with vascular stimulation, namely the application of venous stasis. Application of venous stasis for 30 min induced the release of t-PA from the vascular endothelium into the perfusate (from 0.19 ± 0.05 to 0.39 ± 0.05 UI/ml), reaching a peak 90 s after reperfusion. Aspirin administered to rats 60 min before the experiments (100 mg/kg i.v.), or dissolved in Tyrode solution (100 μM), suppressed 6-keto-prostaglandin F (6-keto-PGF) synthesis (0.38 ± 0.09 in control and

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - Dec 8 1992


  • Aspirin
  • Fibrinolytic activity
  • Venous stasis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology


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