Effect of antiepileptic drugs on sleep

Fabio Placidi, Anna Scalise, Maria Grazia Marciani, Andrea Romigi, Marina Diomedi, Gian Luigi Gigli

Research output: Contribution to journalArticlepeer-review


The interactions between sleep and epilepsy are well known. A nodal point of the relationship between sleep and epilepsy is represented by pharmacological treatment. Sleep disturbances such as drowsiness are among the most frequent side effects of treatment with antiepileptic drugs, since they can deeply modify both sleep architecture and the sleep-wake cycle. Severe daytime somnolence affects patients' activities and it may facilitate the occurrence of seizures. These considerations underline the importance of antiepileptic drugs having anticonvulsant properties that do not negatively influence sleep and daytime somnolence. In this paper we review some relevant aspects of the effects of antiepileptic drugs on sleep. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
JournalClinical Neurophysiology
Issue numberSUPPL. 2
Publication statusPublished - Sept 1 2000


  • Antiepileptic drugs
  • Epilepsy
  • Polysomnography
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems


Dive into the research topics of 'Effect of antiepileptic drugs on sleep'. Together they form a unique fingerprint.

Cite this