TY - JOUR
T1 - Echocardiographic alterations in patients with non-functioning adrenal incidentaloma
AU - Ermetici, F.
AU - Dall'Asta, C.
AU - Malavazos, A. E.
AU - Coman, C.
AU - Morricone, L.
AU - Montericcio, V.
AU - Ambrosi, Bruno
PY - 2008/6
Y1 - 2008/6
N2 - Objective: While left ventricular (LV) dysfunction has been described in patients with Cushing's syndrome (CS), data concerning morphologic and functional cardiac alterations in patients with incidentally discovered adrenal masses [adrenal "incidentaloma" (AI)], without overt hypercortisolism, are lacking. In this study the echocardiographic characteristics of patients with AI were evaluated and then compared with those of lean and obese normotensive subjects. Subjects and methods: Twenty-one patients with AI, without clinical or subclinical hypercortisolism, 18 normotensive obese subjects matched for gender and body mass index (BMI) and 20 normotensive lean subjects were studied. Echocardiography was performed in all subjects. In all patients plasma ACTH, serum cortisol, and DHEA-S levels were measured. Results: Patients with AI showed greater impairment of several echocardiographic indices of LV hypertrophy and diastolic dysfunction compared to normotensive lean subjects (p
AB - Objective: While left ventricular (LV) dysfunction has been described in patients with Cushing's syndrome (CS), data concerning morphologic and functional cardiac alterations in patients with incidentally discovered adrenal masses [adrenal "incidentaloma" (AI)], without overt hypercortisolism, are lacking. In this study the echocardiographic characteristics of patients with AI were evaluated and then compared with those of lean and obese normotensive subjects. Subjects and methods: Twenty-one patients with AI, without clinical or subclinical hypercortisolism, 18 normotensive obese subjects matched for gender and body mass index (BMI) and 20 normotensive lean subjects were studied. Echocardiography was performed in all subjects. In all patients plasma ACTH, serum cortisol, and DHEA-S levels were measured. Results: Patients with AI showed greater impairment of several echocardiographic indices of LV hypertrophy and diastolic dysfunction compared to normotensive lean subjects (p
KW - Adrenal incidentaloma
KW - Cardiac function
KW - Cortisol
KW - Echocardiography
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M3 - Article
C2 - 18591893
AN - SCOPUS:48449087747
SN - 0391-4097
VL - 31
SP - 573
EP - 577
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
IS - 6
ER -