Echocardiographic alterations in patients with non-functioning adrenal incidentaloma

F. Ermetici, C. Dall'Asta, A. E. Malavazos, C. Coman, L. Morricone, V. Montericcio, Bruno Ambrosi

Research output: Contribution to journalArticlepeer-review


Objective: While left ventricular (LV) dysfunction has been described in patients with Cushing's syndrome (CS), data concerning morphologic and functional cardiac alterations in patients with incidentally discovered adrenal masses [adrenal "incidentaloma" (AI)], without overt hypercortisolism, are lacking. In this study the echocardiographic characteristics of patients with AI were evaluated and then compared with those of lean and obese normotensive subjects. Subjects and methods: Twenty-one patients with AI, without clinical or subclinical hypercortisolism, 18 normotensive obese subjects matched for gender and body mass index (BMI) and 20 normotensive lean subjects were studied. Echocardiography was performed in all subjects. In all patients plasma ACTH, serum cortisol, and DHEA-S levels were measured. Results: Patients with AI showed greater impairment of several echocardiographic indices of LV hypertrophy and diastolic dysfunction compared to normotensive lean subjects (p

Original languageEnglish
Pages (from-to)573-577
Number of pages5
JournalJournal of Endocrinological Investigation
Issue number6
Publication statusPublished - Jun 2008


  • Adrenal incidentaloma
  • Cardiac function
  • Cortisol
  • Echocardiography

ASJC Scopus subject areas

  • Endocrinology


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