Early pregnancy loss: the default outcome for fertilized human oocytes

The Annual Capri Workshop Group, Piergiorgio Crosignani, Edgardo Somigliana

Research output: Contribution to journalReview articlepeer-review


Early pregnancy loss is by far the most frequent outcome of human reproduction. It occurs when despite the timely interaction of gametes and initiation of embryogenesis and implantation of the conceptus, pregnancy continuance fails. From a clinical perspective, early pregnancy loss represents a neglected but relevant issue because of the high incidence, the evolving and yet not fully elucidated mechanism, the possible association with other relevant medical conditions, and the potential psychological sequelae. Our growing understanding of the dialog established between the embryo and the endometrium provides new insights into the etiology of pregnancy loss. Aneuploidies as a cause of early pregnancy loss are known for a long time, but there is now evidence that endometrium is not a passive player. An active selection aimed at impeding implantation of unhealthy embryos actually occurs at the endometrial interface. The concept of selectivity is substituting the one of mere receptivity.

Original languageEnglish
Pages (from-to)1057-1063
JournalJournal of Assisted Reproduction and Genetics
Issue number5
Publication statusPublished - 2020


  • Cardiovascular risks
  • Endometrium
  • Genetic testing
  • Implantation
  • Miscarriage
  • Misoprostol
  • Pregnancy loss

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics(clinical)


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