TY - JOUR
T1 - Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis
AU - Sicignano, Ludovico Luca
AU - Massaro, Maria Grazia
AU - Savino, Marinica
AU - Rigante, Donato
AU - Gerardino, Laura
AU - Manna, Raffaele
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/8
Y1 - 2021/8
N2 - The clinical response to anakinra observed by this patient concurrently treated with antibiotics indirectly confirms the potentially pathogenic role of IL-1 in maintaining the pericardial disease and shows how IL-1 blockade might allow avoiding the pericardiocentesis procedure. The report supports the hypothesis that anakinra is an effective and safe tool in the early treatment of acute pericarditis of presumed bacterial origin nonresponding to targeted antibiotic therapy.
AB - The clinical response to anakinra observed by this patient concurrently treated with antibiotics indirectly confirms the potentially pathogenic role of IL-1 in maintaining the pericardial disease and shows how IL-1 blockade might allow avoiding the pericardiocentesis procedure. The report supports the hypothesis that anakinra is an effective and safe tool in the early treatment of acute pericarditis of presumed bacterial origin nonresponding to targeted antibiotic therapy.
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U2 - 10.1007/s11739-020-02627-2
DO - 10.1007/s11739-020-02627-2
M3 - Article
C2 - 33475973
AN - SCOPUS:85099941420
SN - 1828-0447
VL - 16
SP - 1391
EP - 1394
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
IS - 5
ER -