Early add-on immunoglobulin administration in Rasmussen encephalitis: The hypothesis of neuroimmunomodulation

L. Papetti, F. Nicita, T. Granata, R. Guerrini, F. Ursitti, E. Properzi, P. Iannetti, A. Spalice

Research output: Contribution to journalArticlepeer-review


Rasmussen encephalitis (RE) is a chronic inflammatory disease leading to unilateral hemispheric atrophy, associated with progressive neurological dysfunction and intractable seizures. The best approach to RE is hemispherectomy. However long-term immunotherapy seems to prevent or slow down hemispheric tissue loss and the associated functional decline.We describe a girl with epilepsia partialis continua (EPC) and progressive neurological dysfunction compatible with RE. The brain MRI showed a lesion that was initially interpreted as focal cortical dysplasia. Combined antiepileptic and immunomodulation were administered for two years with initial beneficial effects. The follow-up MRI, 4 year later showed. atrophic change in right parietal region.The association of antiepileptic and immunomodulation therapies may inhibit pathogenetic mechanisms responsible for neuronal loss in RE, slowing down the progression of the disease.

Original languageEnglish
Pages (from-to)917-920
Number of pages4
JournalMedical Hypotheses
Issue number5
Publication statusPublished - Nov 2011

ASJC Scopus subject areas

  • Medicine(all)


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