E-cadherin loss and ΔNP73L expression in oral squamous cell carcinomas showing aggressive behavior

Maria P. Foschini; Roberto Cocchi; Luca Morandi; Gianluca Marucci; Maria G. Pennesi; Alberto Righi; Anna L. Tosi; Dario De Biase; Annalisa Pession; Lucio Montebugnoli

doi:10.1002/hed.20908

E-cadherin loss and ΔNP73L expression in oral squamous cell carcinomas showing aggressive behavior

Maria P. Foschini, Roberto Cocchi, Luca Morandi, Gianluca Marucci, Maria G. Pennesi, Alberto Righi, Anna L. Tosi, Dario De Biase, Annalisa Pession, Lucio Montebugnoli

Research output: Contribution to journal › Article › peer-review

Abstract

Background. This article sought to investigate the existence of parameters useful for predicting lymph node metastases in cases of surgically resected oral squamous cell carcinomas (OSCCs). Methods. Fifty-eight cases were studied for E-cadherin and the truncated dominant-negative isoform of p63 (ΔNp63) with immunohistochemistry. In addition, the p63 gene expression profile was evaluated by reverse transcriptase-polymerase chain reaction (RTPCR) to disclose the presence of the truncated variant ΔNp73L. Results. E-cadherin expression was the most powerful parameter related to the presence of lymph node metastases at presentation. Twenty-four of 38 (63%) cases showing low E-cadherin expression had lymph node metastases at presentation compared with 5 of 20 (25%) (p

Original language	English
Pages (from-to)	1475-1482
Number of pages	8
Journal	Head and Neck
Volume	30
Issue number	11
DOIs	https://doi.org/10.1002/hed.20908
Publication status	Published - Nov 2008

Keywords

ΔNp73L
E-cadherin
Lymph node metastasis
p63
Squamous cell carcinoma

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.20908

Cite this

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title = "E-cadherin loss and ΔNP73L expression in oral squamous cell carcinomas showing aggressive behavior",

abstract = "Background. This article sought to investigate the existence of parameters useful for predicting lymph node metastases in cases of surgically resected oral squamous cell carcinomas (OSCCs). Methods. Fifty-eight cases were studied for E-cadherin and the truncated dominant-negative isoform of p63 (ΔNp63) with immunohistochemistry. In addition, the p63 gene expression profile was evaluated by reverse transcriptase-polymerase chain reaction (RTPCR) to disclose the presence of the truncated variant ΔNp73L. Results. E-cadherin expression was the most powerful parameter related to the presence of lymph node metastases at presentation. Twenty-four of 38 (63%) cases showing low E-cadherin expression had lymph node metastases at presentation compared with 5 of 20 (25%) (p ",

keywords = "ΔNp73L, E-cadherin, Lymph node metastasis, p63, Squamous cell carcinoma",

author = "Foschini, {Maria P.} and Roberto Cocchi and Luca Morandi and Gianluca Marucci and Pennesi, {Maria G.} and Alberto Righi and Tosi, {Anna L.} and {De Biase}, Dario and Annalisa Pession and Lucio Montebugnoli",

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AU - Foschini, Maria P.

AU - Cocchi, Roberto

AU - Morandi, Luca

AU - Marucci, Gianluca

AU - Pennesi, Maria G.

AU - Righi, Alberto

AU - Tosi, Anna L.

AU - De Biase, Dario

AU - Pession, Annalisa

AU - Montebugnoli, Lucio

PY - 2008/11

Y1 - 2008/11

N2 - Background. This article sought to investigate the existence of parameters useful for predicting lymph node metastases in cases of surgically resected oral squamous cell carcinomas (OSCCs). Methods. Fifty-eight cases were studied for E-cadherin and the truncated dominant-negative isoform of p63 (ΔNp63) with immunohistochemistry. In addition, the p63 gene expression profile was evaluated by reverse transcriptase-polymerase chain reaction (RTPCR) to disclose the presence of the truncated variant ΔNp73L. Results. E-cadherin expression was the most powerful parameter related to the presence of lymph node metastases at presentation. Twenty-four of 38 (63%) cases showing low E-cadherin expression had lymph node metastases at presentation compared with 5 of 20 (25%) (p

AB - Background. This article sought to investigate the existence of parameters useful for predicting lymph node metastases in cases of surgically resected oral squamous cell carcinomas (OSCCs). Methods. Fifty-eight cases were studied for E-cadherin and the truncated dominant-negative isoform of p63 (ΔNp63) with immunohistochemistry. In addition, the p63 gene expression profile was evaluated by reverse transcriptase-polymerase chain reaction (RTPCR) to disclose the presence of the truncated variant ΔNp73L. Results. E-cadherin expression was the most powerful parameter related to the presence of lymph node metastases at presentation. Twenty-four of 38 (63%) cases showing low E-cadherin expression had lymph node metastases at presentation compared with 5 of 20 (25%) (p

KW - ΔNp73L

KW - E-cadherin

KW - Lymph node metastasis

KW - p63

KW - Squamous cell carcinoma

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E-cadherin loss and ΔNP73L expression in oral squamous cell carcinomas showing aggressive behavior

Abstract

Keywords

ASJC Scopus subject areas

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