Dyslipidaemia in children on renal replacement therapy

Marjolein Bonthuis, Karlijn J. Van Stralen, Kitty J. Jager, Sergey Baiko, Timo Jahnukainen, Guido F. Laube, Ludmila Podracka, Tomás Seeman, Kay Tyerman, Tim Ulinski, Jaap W. Groothoff, Franz Schaefer, Enrico Verrina

Research output: Contribution to journalArticlepeer-review


BackgroundInformation on lipid abnormalities in end-stage renal disease (ESRD) mainly originates from adult patients and small paediatric studies. We describe the prevalence of dyslipidaemia, and potential determinants associated with lipid measures in a large cohort of paediatric ESRD patients.MethodsIn the ESPN/ERA-EDTA registry, lipid measurements were available for 976 patients aged 2-17 years from 19 different countries from the year 2000 onwards. Dyslipidaemia was defined as triglycerides >100 mg/dL (2-9 years) or >130 mg/dL (9-17 years), high-density lipoprotein (HDL) cholesterol 145 mg/dL. Missing data were supplemented using multiple imputation.ResultsThe prevalence of dyslipidaemia was 85.1% in peritoneal dialysis (PD) patients, 76.1% in haemodialysis (HD) patients and 55.5% among renal allograft recipients. Both low and high body mass index (BMI) were associated with a less favourable lipid profile. Younger age was associated with a worse lipid profile among PD patients. HDL levels significantly improved after transplantation, whereas no significant improvements were found for triglyceride and non-HDL levels. In transplant recipients, use of cyclosporin was associated with significantly higher non-HDL and HDL levels than tacrolimus usage (P <0.01). In transplant patients with eGFR <29 mL/min/1.73 m 2, the mean triglyceride level was 137 mg/dL (99% confidence interval (CI): 119-159) compared with 102 mg/dL among those with eGFR > 90 mL/min/1.73 m2 (P <0.0001).ConclusionsDyslipidaemia is common among paediatric ESRD patients in Europe. Young age and PD treatment are associated with worse lipid profiles. Although lipid levels generally improve after transplantation, dyslipidaemia may persist due to decreased graft function, high BMI or to the use of certain immunosuppressants.

Original languageEnglish
Pages (from-to)594-603
Number of pages10
JournalNephrology Dialysis Transplantation
Issue number3
Publication statusPublished - 2014


  • Children
  • Dialysis
  • Dyslipidaemia
  • Renal replacement therapy
  • Transplantation

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Medicine(all)


Dive into the research topics of 'Dyslipidaemia in children on renal replacement therapy'. Together they form a unique fingerprint.

Cite this