Dynamic contrast-enhanced (DCE) imaging: state of the art and applications in whole-body imaging

On behalf of the Young SIRM Working Group, Domenico Albano, Federico Bruno, Andrea Agostini, Salvatore Alessio Angileri, Massimo Benenati, Giulia Bicchierai, Michaela Cellina, Vito Chianca, Diletta Cozzi, Ginevra Danti, Federica De Muzio, Letizia Di Meglio, Francesco Gentili, Giuliana Giacobbe, Giulia Grazzini, Irene Grazzini, Pasquale Guerriero, Carmelo Messina, Giuseppe MicciPierpaolo Palumbo, Maria Paola Rocco, Roberto Grassi, Vittorio Miele, Antonio Barile

Research output: Contribution to journalReview articlepeer-review


Dynamic contrast-enhanced (DCE) imaging is a non-invasive technique used for the evaluation of tissue vascularity features through imaging series acquisition after contrast medium administration. Over the years, the study technique and protocols have evolved, seeing a growing application of this method across different imaging modalities for the study of almost all body districts. The main and most consolidated current applications concern MRI imaging for the study of tumors, but an increasing number of studies are evaluating the use of this technique also for inflammatory pathologies and functional studies. Furthermore, the recent advent of artificial intelligence techniques is opening up a vast scenario for the analysis of quantitative information deriving from DCE. The purpose of this article is to provide a comprehensive update on the techniques, protocols, and clinical applications – both established and emerging – of DCE in whole-body imaging.

Original languageEnglish
Pages (from-to)341-366
JournalJapanese Journal of Radiology
Issue number4
Publication statusPublished - 2022


  • DCE
  • MRI
  • Oncology
  • Radiomics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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