Duration of exposure to environmental carcinogens affects DNA-adduct level in human lymphocytes

Alberto Izzotti; Alessandra Pulliero; Riccardo Puntoni; Marco Peluso; Rosangela Filiberti; Armelle Munnia; Giorgio Assennato; Giovanni Ferri; Domenico Franco Merlo

doi:10.3109/1354750X.2010.497870

Duration of exposure to environmental carcinogens affects DNA-adduct level in human lymphocytes

Alberto Izzotti, Alessandra Pulliero, Riccardo Puntoni, Marco Peluso, Rosangela Filiberti, Armelle Munnia, Giorgio Assennato, Giovanni Ferri, Domenico Franco Merlo

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Background and objective: An important issue in human biomonitoring is determining how exposure duration affects the kinetics of molecular biomarkers. In this study we compare the influence of exposure variables on DNA adducts. Methods: DNA adducts were analysed by 32P-postlabelling in lympho/monocytes of 677 Caucasian subjects. Results: After correction for other variables, DNA adducts increased depending on the length of occupational and smoke exposures. Higher DNA adducts were detected in workers with more than 14 years of exposure than in workers with shorter exposures (RR1=.19, p=0.049) and in smokers with more than 10 years of exposure than in smokers with shorter exposure (RR=1.21, p

Original language	English
Pages (from-to)	575-582
Number of pages	8
Journal	Biomarkers
Volume	15
Issue number	7
DOIs	https://doi.org/10.3109/1354750X.2010.497870
Publication status	Published - Nov 2010

Keywords

Chronic exposure
DNA adducts
Human biomonitoring

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2010.497870

Cite this

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title = "Duration of exposure to environmental carcinogens affects DNA-adduct level in human lymphocytes",

abstract = "Background and objective: An important issue in human biomonitoring is determining how exposure duration affects the kinetics of molecular biomarkers. In this study we compare the influence of exposure variables on DNA adducts. Methods: DNA adducts were analysed by 32P-postlabelling in lympho/monocytes of 677 Caucasian subjects. Results: After correction for other variables, DNA adducts increased depending on the length of occupational and smoke exposures. Higher DNA adducts were detected in workers with more than 14 years of exposure than in workers with shorter exposures (RR1=.19, p=0.049) and in smokers with more than 10 years of exposure than in smokers with shorter exposure (RR=1.21, p ",

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AU - Izzotti, Alberto

AU - Pulliero, Alessandra

AU - Puntoni, Riccardo

AU - Peluso, Marco

AU - Filiberti, Rosangela

AU - Munnia, Armelle

AU - Assennato, Giorgio

AU - Ferri, Giovanni

AU - Merlo, Domenico Franco

PY - 2010/11

Y1 - 2010/11

N2 - Background and objective: An important issue in human biomonitoring is determining how exposure duration affects the kinetics of molecular biomarkers. In this study we compare the influence of exposure variables on DNA adducts. Methods: DNA adducts were analysed by 32P-postlabelling in lympho/monocytes of 677 Caucasian subjects. Results: After correction for other variables, DNA adducts increased depending on the length of occupational and smoke exposures. Higher DNA adducts were detected in workers with more than 14 years of exposure than in workers with shorter exposures (RR1=.19, p=0.049) and in smokers with more than 10 years of exposure than in smokers with shorter exposure (RR=1.21, p

AB - Background and objective: An important issue in human biomonitoring is determining how exposure duration affects the kinetics of molecular biomarkers. In this study we compare the influence of exposure variables on DNA adducts. Methods: DNA adducts were analysed by 32P-postlabelling in lympho/monocytes of 677 Caucasian subjects. Results: After correction for other variables, DNA adducts increased depending on the length of occupational and smoke exposures. Higher DNA adducts were detected in workers with more than 14 years of exposure than in workers with shorter exposures (RR1=.19, p=0.049) and in smokers with more than 10 years of exposure than in smokers with shorter exposure (RR=1.21, p

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Duration of exposure to environmental carcinogens affects DNA-adduct level in human lymphocytes

Abstract

Keywords

ASJC Scopus subject areas

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