Double-blind trial of dexamethasone versus methylprednisolone in multiple sclerosis acute relapses

L. La Mantia; M. Eoli; C. Milanese; A. Salmaggi; A. Dufour; V. Torri

doi:10.1159/000117038

Double-blind trial of dexamethasone versus methylprednisolone in multiple sclerosis acute relapses

L. La Mantia, M. Eoli, C. Milanese, A. Salmaggi, A. Dufour, V. Torri

Research output: Contribution to journal › Article › peer-review

Abstract

The efficacy of dexamethasone (DX) and methylprednisolone (MP) at high (HD) and low (LD) dose in acute multiple sclerosis (MS) relapses was evaluated by a double-blind trial in 31 patients followed for 1 year. DX and HDMP were similarly efficacious in promoting recovery, while LDMP was ineffective in the short-term outcome and was followed by an early clinical reactivation. The different outcomes seem to be related to different immunomodulating effects, mainly on cerebrospinal fluid (CSF) IgG synthesis and on peripheral blood and CSF CD4⁺ lymphocyte subsets.

Original language	English
Pages (from-to)	199-203
Number of pages	5
Journal	European Neurology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1159/000117038
Publication status	Published - 1994

Keywords

Multiple sclerosis
Relapse
Steroids

ASJC Scopus subject areas

Clinical Neurology
Neurology

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abstract = "The efficacy of dexamethasone (DX) and methylprednisolone (MP) at high (HD) and low (LD) dose in acute multiple sclerosis (MS) relapses was evaluated by a double-blind trial in 31 patients followed for 1 year. DX and HDMP were similarly efficacious in promoting recovery, while LDMP was ineffective in the short-term outcome and was followed by an early clinical reactivation. The different outcomes seem to be related to different immunomodulating effects, mainly on cerebrospinal fluid (CSF) IgG synthesis and on peripheral blood and CSF CD4+ lymphocyte subsets.",

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AU - Salmaggi, A.

AU - Dufour, A.

AU - Torri, V.

PY - 1994

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AB - The efficacy of dexamethasone (DX) and methylprednisolone (MP) at high (HD) and low (LD) dose in acute multiple sclerosis (MS) relapses was evaluated by a double-blind trial in 31 patients followed for 1 year. DX and HDMP were similarly efficacious in promoting recovery, while LDMP was ineffective in the short-term outcome and was followed by an early clinical reactivation. The different outcomes seem to be related to different immunomodulating effects, mainly on cerebrospinal fluid (CSF) IgG synthesis and on peripheral blood and CSF CD4+ lymphocyte subsets.

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KW - Steroids

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Double-blind trial of dexamethasone versus methylprednisolone in multiple sclerosis acute relapses

Abstract

Keywords

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