Dose-dependent kinetics of caffeine in rats

R. Latini; M. Bonati; D. Castelli; S. Garattini

doi:10.1016/0378-4274(78)90024-3

Dose-dependent kinetics of caffeine in rats

R. Latini, M. Bonati, D. Castelli, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Caffeine was administered orally to male rats at 3 different doses (1, 10, 100 mg/kg). Plasma and brain concentrations were measured and kinetic parameters calculated. Ratios between doses were much lower than between areas under the curve in plasma as well as in brain. Brain:plasma ratios changed with the dose. Dose-dependent kinetics of caffeine in elimination and absorption is apparent.

Original language	English
Pages (from-to)	267-270
Number of pages	4
Journal	Toxicology Letters
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/0378-4274(78)90024-3
Publication status	Published - 1978

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(78)90024-3

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title = "Dose-dependent kinetics of caffeine in rats",

abstract = "Caffeine was administered orally to male rats at 3 different doses (1, 10, 100 mg/kg). Plasma and brain concentrations were measured and kinetic parameters calculated. Ratios between doses were much lower than between areas under the curve in plasma as well as in brain. Brain:plasma ratios changed with the dose. Dose-dependent kinetics of caffeine in elimination and absorption is apparent.",

author = "R. Latini and M. Bonati and D. Castelli and S. Garattini",

year = "1978",

doi = "10.1016/0378-4274(78)90024-3",

language = "English",

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journal = "Toxicology Letters",

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TY - JOUR

T1 - Dose-dependent kinetics of caffeine in rats

AU - Latini, R.

AU - Bonati, M.

AU - Castelli, D.

AU - Garattini, S.

PY - 1978

Y1 - 1978

N2 - Caffeine was administered orally to male rats at 3 different doses (1, 10, 100 mg/kg). Plasma and brain concentrations were measured and kinetic parameters calculated. Ratios between doses were much lower than between areas under the curve in plasma as well as in brain. Brain:plasma ratios changed with the dose. Dose-dependent kinetics of caffeine in elimination and absorption is apparent.

AB - Caffeine was administered orally to male rats at 3 different doses (1, 10, 100 mg/kg). Plasma and brain concentrations were measured and kinetic parameters calculated. Ratios between doses were much lower than between areas under the curve in plasma as well as in brain. Brain:plasma ratios changed with the dose. Dose-dependent kinetics of caffeine in elimination and absorption is apparent.

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U2 - 10.1016/0378-4274(78)90024-3

DO - 10.1016/0378-4274(78)90024-3

M3 - Article

AN - SCOPUS:0018166530

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VL - 2

SP - 267

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JO - Toxicology Letters

JF - Toxicology Letters

IS - 5

ER -

Dose-dependent kinetics of caffeine in rats

Abstract

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