Dose-dependent kinetics of caffeine in rats

Research output: Contribution to journalArticlepeer-review


Caffeine was administered orally to male rats at 3 different doses (1, 10, 100 mg/kg). Plasma and brain concentrations were measured and kinetic parameters calculated. Ratios between doses were much lower than between areas under the curve in plasma as well as in brain. Brain:plasma ratios changed with the dose. Dose-dependent kinetics of caffeine in elimination and absorption is apparent.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalToxicology Letters
Issue number5
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Toxicology


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