Caffeine was administered orally to male rats at 3 different doses (1, 10, 100 mg/kg). Plasma and brain concentrations were measured and kinetic parameters calculated. Ratios between doses were much lower than between areas under the curve in plasma as well as in brain. Brain:plasma ratios changed with the dose. Dose-dependent kinetics of caffeine in elimination and absorption is apparent.
|Number of pages||4|
|Publication status||Published - 1978|
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