Dopamine metabolism and receptor function after acute and chronic ethanol

A. Reggiani, M. L. Barbaccia, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review


Acute ethanol treatment in rats elicits a selective increase in dihydroxyphenylacetic acid (DOPAC) content in striatum. In contrast, striatal DOPAC concentration does not differ from normal values after chronic ethanol treatment. Chronic administration of ethanol however causes a selective increase of specific [3H]spiroperidol binding and met-enkephalin content in the striatum. Kinetic analysis of [3H]spiroperidol binding data shows that after chronic ethanol treatment there is a significant increase in the affinity constant rather than in the number of binding sites for the ligand. Our results support the hypothesis that dopaminergic mechanisms at both pre- and postsynaptic level may be involved in the mediation of some of the central effects observed after ethanol consumption.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalJournal of Neurochemistry
Issue number1
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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