TY - JOUR
T1 - Donepezil effects on sources of cortical rhythms in mild Alzheimer's disease
T2 - Responders vs. Non-Responders
AU - Babiloni, Claudio
AU - Cassetta, Emanuele
AU - Dal Forno, Gloria
AU - Del Percio, Claudio
AU - Ferreri, Florinda
AU - Ferri, Raffaele
AU - Lanuzza, Bartolo
AU - Miniussi, Carlo
AU - Moretti, Davide V.
AU - Nobili, Flavio
AU - Pascual-Marqui, Roberto D.
AU - Rodriguez, Guido
AU - Luca Romani, Gian
AU - Salinari, Serenella
AU - Zanetti, Orazio
AU - Rossini, Paolo M.
PY - 2006/7/15
Y1 - 2006/7/15
N2 - Acetylcholinesterase inhibitors (AChEI) such as donepezil act in mild Alzheimer's disease (AD) by increasing cholinergic tone. Differences in the clinical response in patients who do or do not benefit from therapy may be due to different functional features of the central neural systems. We tested this hypothesis using cortical electroencephalographic (EEG) rhythmicity. Resting eyes-closed EEG data were recorded in 58 mild AD patients (Mini Mental State Examination [MMSE] range 17-24) before and approximately 1 year after standard donepezil treatment. Based on changes of MMSE scores between baseline and follow-up, 28 patients were classified as "Responders" (MMSEvar ≥ 0) and 30 patients as "Non-Responders" (MMSEvar <0). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Cortical EEG sources were studied with low-resolution brain electromagnetic tomography (LORETA). Before treatment, posterior sources of delta, alpha 1 and alpha 2 frequencies were greater in amplitude in Non-Responders. After treatment, a lesser magnitude reduction of occipital and temporal alpha 1 sources characterized Responders. These results suggest that Responders and Non-Responders had different EEG cortical rhythms. Donepezil could act by reactivating existing yet functionally silent cortical synapses in Responders, restoring temporal and occipital alpha rhythms.
AB - Acetylcholinesterase inhibitors (AChEI) such as donepezil act in mild Alzheimer's disease (AD) by increasing cholinergic tone. Differences in the clinical response in patients who do or do not benefit from therapy may be due to different functional features of the central neural systems. We tested this hypothesis using cortical electroencephalographic (EEG) rhythmicity. Resting eyes-closed EEG data were recorded in 58 mild AD patients (Mini Mental State Examination [MMSE] range 17-24) before and approximately 1 year after standard donepezil treatment. Based on changes of MMSE scores between baseline and follow-up, 28 patients were classified as "Responders" (MMSEvar ≥ 0) and 30 patients as "Non-Responders" (MMSEvar <0). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Cortical EEG sources were studied with low-resolution brain electromagnetic tomography (LORETA). Before treatment, posterior sources of delta, alpha 1 and alpha 2 frequencies were greater in amplitude in Non-Responders. After treatment, a lesser magnitude reduction of occipital and temporal alpha 1 sources characterized Responders. These results suggest that Responders and Non-Responders had different EEG cortical rhythms. Donepezil could act by reactivating existing yet functionally silent cortical synapses in Responders, restoring temporal and occipital alpha rhythms.
KW - Alpha rhythm
KW - Donepezil
KW - Electroencephalography (EEG)
KW - Low resolution brain electromagnetic tomography (LORETA)
KW - Mild Alzheimer's disease (mild AD)
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U2 - 10.1016/j.neuroimage.2006.02.015
DO - 10.1016/j.neuroimage.2006.02.015
M3 - Article
C2 - 16600641
AN - SCOPUS:33745209882
SN - 1053-8119
VL - 31
SP - 1650
EP - 1665
JO - NeuroImage
JF - NeuroImage
IS - 4
ER -