Do Mutations Turn p53 into an Oncogene?

Consuelo Pitolli, Ying Wang, Mara Mancini, Yufang Shi, Gerry Melino, Ivano Amelio

Research output: Contribution to journalReview articlepeer-review


The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Issue number24
Publication statusPublished - Dec 11 2019


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