DNA amplification in human gastric carcinomas

O. Mor; G. N. Ranzani; Y. Ravia; G. Rotman; M. Gutman; A. Manor; D. Amadori; J. Houldsworth; M. Hollstein; M. Schwab; Y. Shiloh

doi:10.1016/0165-4608(93)90217-A

DNA amplification in human gastric carcinomas

O. Mor, G. N. Ranzani, Y. Ravia, G. Rotman, M. Gutman, A. Manor, D. Amadori, J. Houldsworth, M. Hollstein, M. Schwab, Y. Shiloh

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

We recently identified a genomic domain at chromosome 10q26 that is highly amplified in the gastric carcinoma cell lines KATO III and SNU-16 and contains the BEK/K-sam gene, which encodes several growth factor receptors. A contiguous segment of 200 kb spanning this gene was amplified in five of 139 (3.6%) primary gastric carcinomas, all of them classified as poorly differentiated tumors. There was no amplification of this genomic region in a variety of other solid tumors. The overall frequency of gene amplification among the gastric carcinomas rose to 19.4% when MYC, ERBB2, and INT2 were included in the analysis, with significant association with advanced tumor stage. Amplification of various genomic regions in solid tumors may be more frequent than previously estimated.

Original language	English
Pages (from-to)	111-114
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	65
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(93)90217-A
Publication status	Published - 1993

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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10.1016/0165-4608(93)90217-A

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title = "DNA amplification in human gastric carcinomas",

abstract = "We recently identified a genomic domain at chromosome 10q26 that is highly amplified in the gastric carcinoma cell lines KATO III and SNU-16 and contains the BEK/K-sam gene, which encodes several growth factor receptors. A contiguous segment of 200 kb spanning this gene was amplified in five of 139 (3.6%) primary gastric carcinomas, all of them classified as poorly differentiated tumors. There was no amplification of this genomic region in a variety of other solid tumors. The overall frequency of gene amplification among the gastric carcinomas rose to 19.4% when MYC, ERBB2, and INT2 were included in the analysis, with significant association with advanced tumor stage. Amplification of various genomic regions in solid tumors may be more frequent than previously estimated.",

author = "O. Mor and Ranzani, {G. N.} and Y. Ravia and G. Rotman and M. Gutman and A. Manor and D. Amadori and J. Houldsworth and M. Hollstein and M. Schwab and Y. Shiloh",

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T1 - DNA amplification in human gastric carcinomas

AU - Mor, O.

AU - Ranzani, G. N.

AU - Ravia, Y.

AU - Rotman, G.

AU - Gutman, M.

AU - Manor, A.

AU - Amadori, D.

AU - Houldsworth, J.

AU - Hollstein, M.

AU - Schwab, M.

AU - Shiloh, Y.

PY - 1993

Y1 - 1993

N2 - We recently identified a genomic domain at chromosome 10q26 that is highly amplified in the gastric carcinoma cell lines KATO III and SNU-16 and contains the BEK/K-sam gene, which encodes several growth factor receptors. A contiguous segment of 200 kb spanning this gene was amplified in five of 139 (3.6%) primary gastric carcinomas, all of them classified as poorly differentiated tumors. There was no amplification of this genomic region in a variety of other solid tumors. The overall frequency of gene amplification among the gastric carcinomas rose to 19.4% when MYC, ERBB2, and INT2 were included in the analysis, with significant association with advanced tumor stage. Amplification of various genomic regions in solid tumors may be more frequent than previously estimated.

AB - We recently identified a genomic domain at chromosome 10q26 that is highly amplified in the gastric carcinoma cell lines KATO III and SNU-16 and contains the BEK/K-sam gene, which encodes several growth factor receptors. A contiguous segment of 200 kb spanning this gene was amplified in five of 139 (3.6%) primary gastric carcinomas, all of them classified as poorly differentiated tumors. There was no amplification of this genomic region in a variety of other solid tumors. The overall frequency of gene amplification among the gastric carcinomas rose to 19.4% when MYC, ERBB2, and INT2 were included in the analysis, with significant association with advanced tumor stage. Amplification of various genomic regions in solid tumors may be more frequent than previously estimated.

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JO - Cancer Genetics and Cytogenetics

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DNA amplification in human gastric carcinomas

Abstract

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