Diurnal blood pressure variation and sympathetic activity

Guido Grassi, Michele Bombelli, Gino Seravalle, Raffaella Dell'Oro, Fosca Quarti-Trevano

Research output: Contribution to journalArticlepeer-review


Blood pressure changes occurring over a 24-h period are under behavioral, humoral and reflex regulation. The sympathetic nervous system modulates blood pressure variation by affecting cardiac output and peripheral vascular resistance. This paper reviews evidence for the relationship between adrenergic neural drive and blood pressure as measured by direct and indirect approaches. This paper also reviews the sympathetic activity associated with increased in-office and out-of-office blood pressure, that is, the white-coat and the masked-hypertensive states. Finally, this paper examines altered neuroadrenergic influences on nocturnal blood pressure reduction and blood pressure variability.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalHypertension Research
Issue number5
Publication statusPublished - May 2010


  • 24-h blood pressure
  • Dipping profile
  • Masked hypertension
  • Sympathetic nervous system
  • White-coat hypertension

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine


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