Distribution of penfluridol in rats and mice

Luisa Airoldi; Franca Marcucci; Emilio Mussini; Silvio Garattini

doi:10.1016/0014-2999(74)90257-X

Distribution of penfluridol in rats and mice

Luisa Airoldi, Franca Marcucci, Emilio Mussini, Silvio Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Penfluridol is a long-lasting neuroleptic drug which accumulates in the adipose tissue of rats and mice. The concentration in this tissue, depending on the time, may be 50-100 times higher than in blood or in brain. Penfluridol does not selectively distribute in various brain areas of rats including hemispheres, striatum, diencephalon, mesencephalon and cerebellum. The concentration of penfluridol in rat brain necessary to exert significant anti-amphetamine activity is around 7 ng/g.

Original language	English
Pages (from-to)	291-295
Number of pages	5
Journal	European Journal of Pharmacology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(74)90257-X
Publication status	Published - 1974

Keywords

Anti-amphetamine effect
Distribution in rats and mice
Neuroleptic drugs
Penfluridol

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(74)90257-X

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title = "Distribution of penfluridol in rats and mice",

abstract = "Penfluridol is a long-lasting neuroleptic drug which accumulates in the adipose tissue of rats and mice. The concentration in this tissue, depending on the time, may be 50-100 times higher than in blood or in brain. Penfluridol does not selectively distribute in various brain areas of rats including hemispheres, striatum, diencephalon, mesencephalon and cerebellum. The concentration of penfluridol in rat brain necessary to exert significant anti-amphetamine activity is around 7 ng/g.",

keywords = "Anti-amphetamine effect, Distribution in rats and mice, Neuroleptic drugs, Penfluridol",

author = "Luisa Airoldi and Franca Marcucci and Emilio Mussini and Silvio Garattini",

year = "1974",

doi = "10.1016/0014-2999(74)90257-X",

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T1 - Distribution of penfluridol in rats and mice

AU - Airoldi, Luisa

AU - Marcucci, Franca

AU - Mussini, Emilio

AU - Garattini, Silvio

PY - 1974

Y1 - 1974

N2 - Penfluridol is a long-lasting neuroleptic drug which accumulates in the adipose tissue of rats and mice. The concentration in this tissue, depending on the time, may be 50-100 times higher than in blood or in brain. Penfluridol does not selectively distribute in various brain areas of rats including hemispheres, striatum, diencephalon, mesencephalon and cerebellum. The concentration of penfluridol in rat brain necessary to exert significant anti-amphetamine activity is around 7 ng/g.

AB - Penfluridol is a long-lasting neuroleptic drug which accumulates in the adipose tissue of rats and mice. The concentration in this tissue, depending on the time, may be 50-100 times higher than in blood or in brain. Penfluridol does not selectively distribute in various brain areas of rats including hemispheres, striatum, diencephalon, mesencephalon and cerebellum. The concentration of penfluridol in rat brain necessary to exert significant anti-amphetamine activity is around 7 ng/g.

KW - Anti-amphetamine effect

KW - Distribution in rats and mice

KW - Neuroleptic drugs

KW - Penfluridol

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

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ER -

Distribution of penfluridol in rats and mice

Abstract

Keywords

ASJC Scopus subject areas

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