Disorders of Ventral Induction/Spectrum of Holoprosencephaly

Sonia Francesca Calloni, Luca Caschera, Fabio Maria Triulzi

Research output: Contribution to journalReview articlepeer-review


Disorders of the ventral induction give rise to a group of congenital malformations that share in common the failure of the prosencephalon cleavage and subsequent formation of midline structures, presenting with a wide spectrum of severity. This article focuses on the imaging findings of the holoprosencephaly spectrum and septo-optic dysplasia, their epidemiology, embryology, and the common clinical associated anomalies. Knowledge of the imaging features of these disorders is necessary for a correct interpretation of findings and accurate parental counseling. Diagnostic evaluation of patients should include molecular screening and genetic counseling to characterize prognosis and risk of recurrence.

Original languageEnglish
Pages (from-to)411-421
Number of pages11
JournalNeuroimaging Clinics of North America
Issue number3
Publication statusPublished - Aug 1 2019


  • Brain
  • Holoprosencephaly
  • Magnetic resonance
  • Neurodevelopment
  • Syntelencephaly
  • Ventral induction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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