Disability in chronic migraine patients with medication overuse: Treatment effects at 1-year follow-up

Licia Grazzi, Frank Andrasik, Domenico D'Amico, Susanna Usai, Steven Kass, Gennaro Bussone

Research output: Contribution to journalArticlepeer-review


Objective.-To determine (1) the clinical course of a sample of chronic migraine patients with drug overuse 6 and 12 months following in-patient treatment and (2) whether functional impairment, assessed by the Migraine Disability Assessment (MIDAS) questionnaire, improved upon treatment. Background.-Patients with chronic migraine and medication overuse are particularly difficult to treat (prophylactic medications that otherwise are effective become ineffective; discontinuation of the offending medication can lead to withdrawal headache; physical and emotional dependence can be present, as well as increased psychological involvement; initial treatment gains can be difficult to maintain). Methods.-Of the 106 patients meeting criteria for chronic migraine with medication overuse, 84 went on to complete a structured in-patient treatment, consisting of medication withdrawal and then prophylactic treatment. Results.-As a group, the patients were improved at both 6- and 12-month follow-up, with respect to two headache parameters (frequency and medication use) and three measures of functional impact extracted from the MIDAS questionnaire (Total Score, Headache Frequency, and Headache Intensity). Conclusion.-Chronic migraine accompanied with medication overuse led to the considerable disability prior to treatment. However, notable improvement occurred coincident with the treatment. This suggests that successful treatment has more wide-ranging positive benefits beyond mere symptom reduction. To our knowledge, this is the first investigation where the MIDAS questionnaire has been used prospectively as an outcome measure in patients with chronic migraine and medication overuse to assess disability subsequent to a semi-standardized treatment program.

Original languageEnglish
Pages (from-to)678-683
Number of pages6
Issue number7
Publication statusPublished - Jul 2004


  • Chronic migraine
  • Disability
  • Drug-induced headache
  • Long-term follow-up

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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