Dimerizable redox-sensitive triazine-based cationic lipids for in vitro gene delivery

Gabriele Candiani; Massimo Frigerio; Fiorenza Viani; Chiara Verpelli; Carlo Sala; Luca Chiamenti; Nadia Zaffaroni; Marco Folini; Monica Sani; Walter Panzeri; Matteo Zanda

doi:10.1002/cmdc.200600267

Dimerizable redox-sensitive triazine-based cationic lipids for in vitro gene delivery

Gabriele Candiani, Massimo Frigerio, Fiorenza Viani, Chiara Verpelli, Carlo Sala, Luca Chiamenti, Nadia Zaffaroni, Marco Folini, Monica Sani, Walter Panzeri, Matteo Zanda

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) The "Trojan Horse" trick works again. Conceptually new melamine-based cationic lipids show excellent transfection efficiency and low cytotoxicity in delivering a DNA plasmid payload to different types of cells, deceiving the natural mechanism of defense toward exogeneous DNA.

Original language	English
Pages (from-to)	292-296
Number of pages	5
Journal	ChemMedChem
Volume	2
Issue number	3
DOIs	https://doi.org/10.1002/cmdc.200600267
Publication status	Published - Mar 12 2007

Keywords

Amphiphiles
DNA
Thiols
Transfection
Triazines

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry
Molecular Medicine

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10.1002/cmdc.200600267

Cite this

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keywords = "Amphiphiles, DNA, Thiols, Transfection, Triazines",

author = "Gabriele Candiani and Massimo Frigerio and Fiorenza Viani and Chiara Verpelli and Carlo Sala and Luca Chiamenti and Nadia Zaffaroni and Marco Folini and Monica Sani and Walter Panzeri and Matteo Zanda",

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AU - Candiani, Gabriele

AU - Frigerio, Massimo

AU - Viani, Fiorenza

AU - Verpelli, Chiara

AU - Sala, Carlo

AU - Chiamenti, Luca

AU - Zaffaroni, Nadia

AU - Folini, Marco

AU - Sani, Monica

AU - Panzeri, Walter

AU - Zanda, Matteo

PY - 2007/3/12

Y1 - 2007/3/12

N2 - (Chemical Equation Presented) The "Trojan Horse" trick works again. Conceptually new melamine-based cationic lipids show excellent transfection efficiency and low cytotoxicity in delivering a DNA plasmid payload to different types of cells, deceiving the natural mechanism of defense toward exogeneous DNA.

AB - (Chemical Equation Presented) The "Trojan Horse" trick works again. Conceptually new melamine-based cationic lipids show excellent transfection efficiency and low cytotoxicity in delivering a DNA plasmid payload to different types of cells, deceiving the natural mechanism of defense toward exogeneous DNA.

KW - Amphiphiles

KW - DNA

KW - Thiols

KW - Transfection

KW - Triazines

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Dimerizable redox-sensitive triazine-based cationic lipids for in vitro gene delivery

Abstract

Keywords

ASJC Scopus subject areas

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